ArticleThe Journal of infectious diseases2014
Preventing biofilm formation and associated occlusion by biomimetic glycocalyxlike polymer in central venous catheters.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 61 citations in OpenAlex.
- Smart Catheters for Diagnosis, Monitoring, and Therapy.Advanced healthcare materials · 2026Review
- Strategies to Prevent Hemodialysis Catheter Dysfunction.Journal of the American Society of Nephrology : JASN · 2025Review
- Current Strategies for Combating Biofilm-Forming Pathogens in Clinical Healthcare-Associated Infections.Indian journal of microbiology · 2024Review
- Medical Device-Associated Biofilm Infections and Multidrug-Resistant Pathogens.Pathogens (Basel, Switzerland) · 2024Review
- Comparison of Tetrasodium EDTA 4% with Sodium Citrate 4% as Line-Locking Solutions at 2 Tertiary Hemodialysis Centres.The Canadian journal of hospital pharmacy · 2024Article
- Effect of a Multifaceted Intervention on the Incidence of Hemodialysis Catheter Dysfunction in a National Stepped-Wedge Cluster Randomized Trial.Kidney international reports · 2023Article
- Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties.Nature communications · 2023Article
- Phyto-assisted synthesis of zinc oxide nanoparticles for developing antibiofilm surface coatings on central venous catheters.Frontiers in chemistry · 2023Article
- Review
- SiOFrontiers in bioengineering and biotechnology · 2022Article
- Human blood plasma factors affect the adhesion kinetics of Staphylococcus aureus to central venous catheters.Scientific reports · 2020Article
- AnBioMed research international · 2020Article
- Article
- Understanding biofilm formation in intravascular device-related infections.Intensive care medicine · 2017Article
- Exploiting Interkingdom Interactions for Development of Small-Molecule Inhibitors of Candida albicans Biofilm Formation.Antimicrobial agents and chemotherapy · 2016Article
- Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Study of in vivo catheter biofilm infections using pediatric central venous catheter implanted in rat.Nature protocols · 2016Article
- Antimicrobial Drugs in Fighting against Antimicrobial Resistance.Frontiers in microbiology · 2016Review
- A new approach to mitigate biofilm formation on totally implantable venous access ports.The Journal of infectious diseases · 2014Article
- Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization.Frontiers in cellular and infection microbiology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of catheters and other implanted devices is constantly increasing in modern medicine. Although catheters improve patients' healthcare, the hydrophobic nature of their surface material promotes protein adsorption and cell adhesion. Catheters are therefore prone to complications, such as colonization by bacterial and fungal biofilms, associated infections, and thrombosis. Here we describe the in vivo efficacy of biologically inspired glycocalyxlike antiadhesive coatings to inhibit Staphylococcus aureus and Pseudomonas aeruginosa colonization on commercial totally implantable venous access ports (TIVAPs) in a clinically relevant rat model of biofilm infection. Although noncoated TIVAPs implanted in rats were heavily colonized by the 2 biofilm-forming pathogens with a high percentage of occlusion, coating TIVAPs reduced their initial adherence and subsequently led to 4-log reduction in biofilm formation and reduced occlusion. Our antiadhesive approach is a simple and generalizable strategy that could be used to minimize clinical complications associated with the use of implantable medical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.