Evidence map›Paper›PMID 24795478›Full record

ArticleThe Journal of infectious diseases2014

Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.

Nischay Mishra, Marcus Pereira, Roy H Rhodes, Ping An, James M Pipas, Komal Jain, Amit Kapoor, Thomas Briese, Phyllis L Faust, W Ian Lipkin

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 159 citations in OpenAlex.

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  10. [Human polyomavirus-associated skin diseases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022
    Review
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  18. Biology of Polyomavirus miRNA.Frontiers in microbiology · 2021
    Review
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  20. Observational

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nischay MishraCenter for Infection and Immunity.
Marcus PereiraDivision of Infectious Diseases, Columbia University, New York, New York.
Roy H RhodesPathology and Laboratory Medicine, Rutgers University, New Brunswick, New Jersey.
Ping AnDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania.
James M PipasDepartment of Biological Sciences, University of Pittsburgh, Pennsylvania.
Komal JainCenter for Infection and Immunity.
Amit KapoorCenter for Infection and Immunity.
Thomas BrieseCenter for Infection and Immunity.
Phyllis L FaustPathology and Cell Biology, Columbia University, New York, New York.
W Ian LipkinCenter for Infection and Immunity.
Institute of Infection and Immunity · CAColumbia University · USUniversity of Pittsburgh · USRutgers, The State University of New Jersey · US

Funding

Viral Pathogenesis and TherapeuticsU54AI057158 · NIAID · WADSWORTH CENTER · PI LEVY, DAVID E · 2003 to 2014
$100.8M
Searching Environmental Metagenomes for Novel Infectious Cancer Agents (PQ12)R21CA170248 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PIPAS, JAMES M · 2012 to 2013
$355k
NCI NIH HHS CA170248NCI NIH HHS R21 CA170248NIAID NIH HHS AI057158NIAID NIH HHS U54 AI057158
6 · The paper itself

Abstract

backgroundA 33 year-old pancreatic transplant recipient developed weakness, retinal blindness, and necrotic plaques on her face, scalp, and hands.

methodsA muscle biopsy was analyzed by light and electron microscopy and high-throughput nucleic acid sequencing.

resultsThe biopsy revealed microthrombosis and viral particles in swollen endothelial cell nuclei. High-throughput sequencing of nucleic acid revealed a novel polyomavirus. In situ hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis and cutaneous necrosis.

conclusionsNew Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothelial cells.

Indexed as

Transplant RecipientsAdultBiopsyBlindnessDNA, ViralEndothelial CellsFemaleHigh-Throughput Nucleotide SequencingHumansIn Situ HybridizationMicroscopyMolecular Sequence DataMusclesMuscular DiseasesPolyomavirus InfectionsRetinitisDNA, Viralimmunosuppressionmyositispolyomavirustransplantationvasculitisvirus discovery

Identifiers

PMID24795478
PMCPMC4334791
OpenAlexW2149046204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.