ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Increased peripheral IL-4 leads to an expanded virtual memory CD8+ population.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Virtual memory CD8⁺ T cells in aging: heterogeneity, bystander protection, inflammatory potential, and inhibitory regulation.Immunity & ageing : I & A · 2026Review
- Eosinophils promote CD8Signal transduction and targeted therapy · 2024Article
- FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors.Journal of biomedical science · 2024Article
- Shaping Heterogeneity of Naive CD8Immune network · 2023Review
- Virtual Memory CD8Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Review
- Exploring the immunomodulatory role of virtual memory CD8Frontiers in immunology · 2022Article
- Self-reactivity controls functional diversity of naive CD8Nature communications · 2021Article
- Signals for antigen-independent differentiation of memory CD8Cellular and molecular life sciences : CMLS · 2021Review
- Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Recent advances in iNKT cell development.F1000Research · 2020Review
- Article
- The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8Cell reports · 2018Article
- Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells.The EMBO journal · 2018Article
- Foreign antigen-independent memory-phenotype CD4Nature reviews. Immunology · 2018Article
- Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice.European journal of immunology · 2018Article
- Memory-phenotype CD4Science immunology · 2017Article
- Antigen-inexperienced memory CD8Nature reviews. Immunology · 2017Article
- IL-4 and IL-15 promotion of virtual memory CD8European journal of immunology · 2016Article
- Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner.Nature communications · 2016Article
- Effect of IL-4 on the Development and Function of Memory-like CD8 T Cells in the Peripheral Lymphoid Tissues.Immune network · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Memory-phenotype CD8(+) T cells can arise even in the absence of overt Ag stimulation. Virtual memory (VM) CD8(+) T cells are CD8(+) T cells that develop a memory phenotype in the periphery of wild-type mice in an IL-15-dependent manner. Innate CD8(+) T cells, in contrast, are memory-phenotype CD8(+) T cells that develop in the thymus in response to elevated thymic IL-4. It is not clear whether VM cells and innate CD8(+) T cells represent two independent T cell lineages or whether they arise through similar processes. In this study, we use mice deficient in Nedd4-family interacting protein 1 to show that overproduction of IL-4 in the periphery leads to an expanded VM population. Nedd4-family interacting protein 1(-/-) CD4(+) T cells produce large amounts of IL-4 due to a defect in JunB degradation. This IL-4 induces a memory-like phenotype in peripheral CD8(+) T cells that includes elevated expression of CD44, CD122, and Eomesodermin and decreased expression of CD49d. Thus, our data show that excess peripheral IL-4 is sufficient to cause an increase in the VM population. Our results suggest that VM and innate CD8(+) T cells may be more similar than previously appreciated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.