Evidence map›Paper›PMID 24795162›Full record

ArticleNeurorehabilitation and neural repair2015

The impact of dynamic balance measures on walking performance in multiple sclerosis.

Nora E Fritz, Rhul Evans R Marasigan, Peter A Calabresi, Scott D Newsome, Kathleen M Zackowski

Open access · bronzeAbstract read
In one paragraph

Article in Neurorehabilitation and neural repair, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Effect of a Combined Program of Strength and Dual Cognitive-Motor Tasks in Multiple Sclerosis Subjects.International journal of environmental research and public health · 2020
    Trial
  4. Gait Kinematics Assessed by ViconSensors (Basel, Switzerland) · 2025
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Vibration Sensitivity Is Associated With Functional Balance After Unilateral Transtibial Amputation.Archives of rehabilitation research and clinical translation · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nora E FritzKennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, Baltimore, MD, USA.
Rhul Evans R MarasiganKennedy Krieger Institute, Baltimore, MD, USA.
Peter A CalabresiJohns Hopkins University, Baltimore, MD, USA.
Scott D NewsomeJohns Hopkins University, Baltimore, MD, USA.
Kathleen M ZackowskiKennedy Krieger Institute, Baltimore, MD, USA Johns Hopkins University, Baltimore, MD, USA zackowski@kennedykrieger.org.
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

MECHANISMS OF LOCOMOTOR RECOVERY IN MULTIPLE SCLEROSISK01HD049476 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ZACKOWSKI, KATHLEEN M. · 2006 to 2010
$499k
NICHD NIH HHS HD049476-04NICHD NIH HHS K01 HD049476
6 · The paper itself

Abstract

backgroundStatic posture imbalance and gait dysfunction are common in individuals with multiple sclerosis (MS). Although the impact of strength and static balance on walking has been examined, the impact of dynamic standing balance on walking in MS remains unclear.

objectiveTo determine the impact of dynamic balance, static balance, sensation, and strength measures on walking in individuals with MS.

methodsFifty-two individuals with MS (27 women; 26 relapsing-remitting; mean age = 45.6 ± 10.3 years; median Expanded Disability Status Scale score = 3.5) participated in posturography testing (Kistler-9281 force plate), hip flexion, hip extension, ankle dorsiflexion strength (Microfet2 hand-held dynamometer), sensation (Vibratron II), and walk velocity (Optotrak Motion Analysis System). Analyses included, Mann-Whitney, Spearman correlation coefficients, and multiple regression.

resultsAll measures were abnormal in individuals with MS when compared with norms (P < .05). Static balance (eyes open, feet together [EOFT]), anterior-posterior (AP) dynamic sway, and hip extension strength were strongly correlated with walking velocity (AP sway r = 0.68; hip extension strength r = 0.73; EOFT r = -0.40). Together, AP dynamic sway (ρr = 0.71; P < .001), hip extension strength (ρr = 0.54; P < .001), and EOFT static balance (ρr = -0.41; P = .01) explained more than 70% of the variance in walking velocity (P < .001).

conclusionsAP dynamic sway affects walking performance in MS. A combined evaluation of dynamic balance, static balance, and strength may lead to a better understanding of walking mechanisms and the development of strategies to improve walking.

Indexed as

AdultDisability EvaluationFemaleGait Disorders, NeurologicHand StrengthHumansMaleMiddle AgedMultiple SclerosisNonlinear DynamicsPostural BalanceRegression AnalysisRetrospective StudiesSensation DisordersWalkingdynamic balancegaitsensationstatic balancestrength

Identifiers

PMID24795162
PMCPMC4216642
OpenAlexW2152729225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.