SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014
Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Hyperbaric oxygen therapy for late radiation tissue injury.The Cochrane database of systematic reviews · 2023Pooled it
- Efficacy and safety of hyperbaric oxygen therapy for fibromyalgia: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2016Pooled it
- Hyperbaric oxygen therapy for late radiation tissue injury.The Cochrane database of systematic reviews · 2016Pooled it
- Efficacy and safety of hyperbaric oxygen therapy for radiation-induced dermatitis in patients with breast cancer: a randomized pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Seizure Occurrence During Hyperbaric Oxygen Therapy: A Case Report and Literature Review.Cureus · 2025Article
- Hyperbaric oxygen therapy: A practical guide for gynecologic oncologists.Gynecologic oncology reports · 2025Review
- Noninvasive Systemic Modalities for Prevention of Head and Neck Radiation-Associated Soft Tissue Injury: A Narrative Review.Journal of reconstructive microsurgery · 2022Review
- Article
- Hyperbaric Oxygen Therapy for Suburethral Vaginal Mucosal Necrosis after Interstitial Irradiation for Recurrent Cervical Cancer.Case reports in obstetrics and gynecology · 2021Article
- Article
- Observational
- Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901.Biomedical reports · 2017Article
- Hyperbaric Oxygen following Bilateral Skin-sparing Mastectomies: A Case Report.Plastic and reconstructive surgery. Global open · 2016Article
- Hyberbaric oxygen as sole treatment for severe radiation - induced haemorrhagic cystitis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this paper was to provide an evidence-based evaluation of the safety and effectiveness of hyperbaric oxygen therapy (HBOT) for the treatment of non-neurological soft tissue radiation-related injuries (STRI).
methodsSystematic searches of medical bibliographic databases, the Internet, and lists of references were conducted in December 2010 and April 2013 to identify relevant primary studies. Inclusion and classification of papers was resolved through the application of a predetermined protocol. Information on both the safety and effectiveness of HBOT was analyzed.
resultsForty-one articles were included, with 11 comparing HBOT to a regimen without HBOT. Comparative evidence varied considerably in methodological quality, and numerous limitations were identified. Absolute data showed that serious adverse events after HBOT were rare, while more common adverse events were minor and self-limiting. Compared to observation, conventional, or sham therapies, evidence of benefit in clinical outcomes was shown for HBOT for radiation proctitis and wounds in irradiated soft tissue of the head and neck, but not for postirradiation soft tissue edema or radiation cystitis. Clinical outcomes differed little between HBOT and argon plasma coagulation for radiation proctitis and between HBOT and hyaluronic acid for radiation cystitis.
conclusionsHBOT is a safe intervention which may offer clinical benefits to patients suffering from radiation proctitis and non-neurological STRI of the head and neck. However, differing clinical responses across STRI demonstrate a need for further well-designed clinical trials to validate the use of HBOT for individual STRI, both as an adjunct to conventional treatments and relative to definitive treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.