Evidence map›Paper›PMID 24794701›Full record

ReviewCurrent opinion in genetics & development2014

SMC complexes link gene expression and genome architecture.

Jill M Dowen, Richard A Young

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. International journal of molecular sciences · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Binding of anGenetics · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Jill M DowenWhitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States.
Richard A YoungWhitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: young@wi.mit.edu.
Massachusetts Institute of Technology · USWhitehead Institute for Biomedical Research · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Transcriptional Regulatory Networks in Living CellsR01HG002668 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI YOUNG, RICHARD · 2003 to 2016
$17.9M
Linking Maintenance of Chromosome Structure to Transcriptional RegulationF32CA168263 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DOWEN, JILL · 2012 to 2014
$163k
NCI NIH HHS CA168263-01A1NCI NIH HHS F32 CA168263NCI NIH HHS P30 CA014051NHGRI NIH HHS HG002668NHGRI NIH HHS R01 HG002668
6 · The paper itself

Abstract

The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.

Indexed as

Gene ExpressionGenomeAnimalsChromosomesGene Expression RegulationHumansMutationTranscription, Genetic

Identifiers

PMID24794701
PMCPMC4045092
OpenAlexW2049701374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.