Evidence map›Paper›PMID 24794644›Full record

ReviewCurrent opinion in virology2014

Mucosal vaccines against respiratory syncytial virus.

Kejian Yang, Steven M Varga

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

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  14. Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation.Journal of controlled release : official journal of the Controlled Release Society · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kejian YangBiomedical Research Models Inc., 10 New Bond Street, Worcester, MA 01606, USA. Electronic address: KYang@biomere.com.
Steven M VargaInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Biomedical Research Models (United States) · USUniversity of Iowa · US

Funding

A Mucosal Vaccine for HSV-2R44AI063820 · NIAID · BIOMEDICAL RESEARCH MODELS, INC. · PI YANG, KEJIAN · 2009 to 2016
$5.6M
Immunopathology mediated by RSV-specific CD4 T cellsR01AI063520 · NIAID · UNIVERSITY OF IOWA · PI VARGA, STEVEN M · 2007 to 2011
$1.8M
A Mucosal RSV VaccineR43AI102292 · NIAID · BIOMEDICAL RESEARCH MODELS, INC. · PI YANG, KEJIAN · 2012 to 2013
$600k
A Mucosal Vaccine for HSV-2R43AI063820 · NIAID · BIOMEDICAL RESEARCH MODELS, INC. · PI TIRABASSI, REBECCA S · 2006 to 2007
$583k
Memory CD8 T cell immunity to respiratory viral infectionsR56AI106776 · NIAID · UNIVERSITY OF IOWA · PI HARTY, JOHN T, VARGA, STEVEN M · 2013 to 2013
$355k
NIAID NIH HHS AI063820NIAID NIH HHS AI102292NIAID NIH HHS R01 AI063520NIAID NIH HHS R43 AI063820NIAID NIH HHS R43 AI102292NIAID NIH HHS R44 AI063820NIAID NIH HHS R56 AI106776PHS HHS CCR922413PHS HHS CCR924378
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease in infants, young children, immune-compromised and elderly populations worldwide. Natural RSV infection in young children does not elicit long-lasting immunity and individuals remain susceptible to repeated RSV infections throughout life. Because RSV infection is restricted to the respiratory tract, an RSV vaccine should elicit mucosal immunity at upper and lower respiratory tracts in order to most effectively prevent RSV reinfection. Although there is no safe and effective RSV vaccine available, significant progress has been recently made in basic RSV research and vaccine development. This review will discuss recent advances in the identification of a new neutralizing antigenic site within the RSV fusion (F) protein, understanding the importance of mucosal immune responses against RSV infection, and the development of novel mucosal vaccination strategies.

Indexed as

Immunity, MucosalAnimalsAntigens, ViralHumansImmunizationMucous MembraneRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesAntigens, ViralRespiratory Syncytial Virus Vaccines

Identifiers

PMID24794644
PMCPMC4079457
OpenAlexW2043519314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.