ReviewCellular and molecular life sciences : CMLS2014
A close look at the mammalian blastocyst: epiblast and primitive endoderm formation.
Review in Cellular and molecular life sciences : CMLS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Profiling of Small Noncoding RNAs During Bovine Conceptus Elongation Identifies Let-7 as a Candidate Regulator of Proliferation and Differentiation.Animals : an open access journal from MDPI · 2026Article
- Defining core signaling pathways for supporting in vitro maintenance of pig extraembryonic endoderm (XEN) cells.Reproduction (Cambridge, England) · 2025Article
- Mir-218-5p from Extracellular Vesicles of Endometrium in Patients with Recurrent Implantation Failure Impairs Pre-Implantation Embryo Development.International journal of nanomedicine · 2025Article
- Using high throughput screens to predict miscarriages with placental stem cells and long-term stress effects with embryonic stem cells.Birth defects research · 2022Review
- Modeling Epiblast Shape in Implanting Mammalian Embryos.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The proteome, not the transcriptome, predicts that oocyte superovulation affects embryonic phenotypes in mice.Scientific reports · 2021Article
- Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo.Cell and tissue research · 2021Review
- SOX2 plays a crucial role in cell proliferation and lineage segregation during porcine pre-implantation embryo development.Cell proliferation · 2021Article
- Gene expression pattern of trophoblast-specific transcription factors in trophectoderm by analysis of single-cell RNA-seq data of human blastocyst.Functional & integrative genomics · 2021Article
- Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach.Scientific reports · 2020Article
- Comparative analysis of the mitochondrial morphology, energy metabolism, and gene expression signatures in three types of blastocyst-derived stem cells.Redox biology · 2020Article
- NANOG is required to form the epiblast and maintain pluripotency in the bovine embryo.Molecular reproduction and development · 2020Article
- Mouse ICM Organoids Reveal Three-Dimensional Cell Fate Clustering.Biophysical journal · 2019Article
- Mesenchymal-epithelial transition in development and reprogramming.Nature cell biology · 2019Review
- Oocyte related factors impacting on embryo quality: relevance forAnimal reproduction · 2018Article
- OCT4/POU5F1 is required for NANOG expression in bovine blastocysts.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Comparative aspects of early lineage specification events in mammalian embryos - insights from reverse genetics studies.Cell cycle (Georgetown, Tex.) · 2018Article
- ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation.Scientific reports · 2017Article
- Prosurvival effect of cumulus prostaglandin G/H synthase 2/prostaglandin2 signaling on bovine blastocyst: impact on in vivo posthatching development.Biology of reproduction · 2017Article
- Does the Aryl Hydrocarbon Receptor Regulate Pluripotency?Current opinion in toxicology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During early development, the mammalian embryo undergoes a series of profound changes that lead to the formation of two extraembryonic tissues--the trophectoderm and the primitive endoderm. These tissues encapsulate the pluripotent epiblast at the time of implantation. The current model proposes that the formation of these lineages results from two consecutive binary cell fate decisions. The first controls the formation of the trophectoderm and the inner cell mass, and the second controls the formation of the primitive endoderm and the epiblast within the inner cell mass. While early mammalian embryos develop with extensive plasticity, the embryonic pattern prior to implantation is remarkably reproducible. Here, we review the molecular mechanisms driving the cell fate decision between primitive endoderm and epiblast in the mouse embryo and integrate data from recent studies into the current model of the molecular network regulating the segregation between these lineages and their subsequent differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.