ArticleCell reports2014
Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 269 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
269 citing papers in PubMed.
- Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome.Gut microbes · 2026Article
- Challenges and Future Directives of Synthetic Biology in Engineering Plant-Microbe Partnerships for Sustainable Agriculture.Biotechnology and bioengineering · 2026Review
- Unraveling the Microbial Associations of Volatile Flavor Profiles in Spontaneously Fermented Camel Milk from Three Regions of Xinjiang, China.Foods (Basel, Switzerland) · 2026Article
- Article
- Microbial Transcriptional and Metabolic Shifts Mediate Rhizosphere Organic Carbon Accumulation in Alpine Grasslands Following Six Years of Continuous Nitrogen Addition.Microorganisms · 2026Article
- Metabolic Modelling Facilitates the Design of Synthetic Communities by Simplifying Natural Microbial Communities.Environmental microbiology · 2026Article
- Next-generation probiotics: an outlook into current applications and future developments.Nature reviews. Microbiology · 2026Review
- Quartet: Disentangling positive and negative components of microbial interactions.PLoS computational biology · 2026Article
- Metabolic set theory: a generalized model of microbial interactions.NPJ systems biology and applications · 2026Article
- Metabolic feedbacks drive population dynamics and can lead to oscillations among leaf bacteria.Nature communications · 2026Article
- MOFA: microbial optimization without forced altruism.BMC bioinformatics · 2026Article
- Dynamical Systems-Constrained Metabolic Modeling Enables Forecasting of Host-Microbiome Dynamics.bioRxiv : the preprint server for biology · 2026Article
- Predictive multispecies constraint-based metabolic modeling: case studies and best practices.Briefings in bioinformatics · 2026Review
- Interplay of Spatial Structure and Interactions in Microbial Communities.Environmental microbiology · 2026Review
- Dynamic metabolic modelling of ATP allocation during viral infection.Journal of the Royal Society, Interface · 2026Article
- Constraint-Based Metabolic Modeling Approach for Microbial Communities.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Chemical organizations as a conceptual tool: from synthetic biology to interdisciplinary systems and back.Frontiers in bioengineering and biotechnology · 2026Article
- Accuracy of the Lotka-Volterra model fails in strongly coupled microbial consumer-resource systems.PLoS computational biology · 2025Article
- Optimization-based framework with flux balance analysis (FBA) and metabolic pathway analysis (MPA) for identifying metabolic objective functions.PLoS computational biology · 2025Article
- Metabolic remodeling of microorganisms by mobile genetic elements alters mutualistic community composition.mSystems · 2025Article
209 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The interspecies exchange of metabolites plays a key role in the spatiotemporal dynamics of microbial communities. This raises the question of whether ecosystem-level behavior of structured communities can be predicted using genome-scale metabolic models for multiple organisms. We developed a modeling framework that integrates dynamic flux balance analysis with diffusion on a lattice and applied it to engineered communities. First, we predicted and experimentally confirmed the species ratio to which a two-species mutualistic consortium converges and the equilibrium composition of a newly engineered three-member community. We next identified a specific spatial arrangement of colonies, which gives rise to what we term the "eclipse dilemma": does a competitor placed between a colony and its cross-feeding partner benefit or hurt growth of the original colony? Our experimentally validated finding that the net outcome is beneficial highlights the complex nature of metabolic interactions in microbial communities while at the same time demonstrating their predictability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.