ArticleCurrent biology : CB2014
Ecdysone mediates the development of immunity in the Drosophila embryo.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 61 citations in OpenAlex.
- Ecdysone signaling acts as a regulator of immunity and microbiota balance, shapingFrontiers in immunology · 2026Article
- Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications.Nature communications · 2025Article
- Azadirachtin disrupts ecdysone signaling and alters sand fly immunity.Parasites & vectors · 2024Article
- Article
- Transcriptomic Profiling of Bean AphidInsects · 2024Article
- Steroid hormone regulation of innate immunity in Drosophila melanogaster.PLoS genetics · 2023Review
- Review
- Macrophage subpopulation identity inFrontiers in immunology · 2023Article
- Immune function of the serosa in hemimetabolous insect eggs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Heightened immune surveillance inHeliyon · 2022Article
- Ecdysone signaling mediates the trade-off between immunity and reproduction via suppression of amyloids in the mosquito Aedes aegypti.PLoS pathogens · 2022Article
- Co-option of immune effectors by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster.PLoS genetics · 2021Article
- Article
- Ecdysone regulates theDevelopment (Cambridge, England) · 2021Article
- The Anti-Inflammatory and Uric Acid Lowering Effects of Si-Miao-San on Gout.Frontiers in immunology · 2021Article
- Temporal specificity and heterogeneity of Drosophila immune cells.The EMBO journal · 2020Article
- 20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae.mSphere · 2020Article
- Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues.Developmental cell · 2019Article
- Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution.PLoS biology · 2019Article
- The Cat Flea (Ctenocephalides felis) Immune Deficiency Signaling Pathway Regulates Rickettsia typhi Infection.Infection and immunity · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Beyond their role in cell metabolism, development, and reproduction, hormones are also important modulators of the immune system. In the context of inflammatory disorders, systemic administration of pharmacological doses of synthetic glucocorticoids (GCs) is widely used as an anti-inflammatory treatment [1, 2]. However, not all actions of GCs are immunosuppressive, and many studies have suggested that physiological concentrations of GCs can have immunoenhancing effects [3-7]. For a more comprehensive understanding of how steroid hormones regulate immunity and inflammation, a simple in vivo system is required. The Drosophila embryo has recently emerged as a powerful model system to study the recruitment of immune cells to sterile wounds [8] and host-pathogen dynamics [9]. Here we investigate the immune response of the fly embryo to bacterial infections and find that the steroid hormone 20-hydroxyecdysone (20-HE) can regulate the quality of the immune response and influence the resolution of infection in Drosophila embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.