Evidence map›Paper›PMID 24794279›Full record

ReviewTrends in cell biology2014

Sorting out a promiscuous superfamily: towards cadherin connectomics.

Marcos Sotomayor, Rachelle Gaudet, David P Corey

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Calcium and CaBrain sciences · 2026
    Review
  4. A Novel Pathogenic Haplotype inBalkan medical journal · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Identification of tumor antigens and immune subtypes of acute myeloid leukemia for mRNA vaccine development.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Orosomucoid-like protein 3, rhinovirus and asthma.World journal of critical care medicine · 2021
    Review
  17. Genome-wide association study identifiesAnnals of the rheumatic diseases · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marcos SotomayorDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus OH 43210, USA. Electronic address: sotomayor.8@osu.edu.
Rachelle GaudetDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: gaudet@mcb.harvard.edu.
David P CoreyHoward Hughes Medical Institute, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dcorey@hms.harvard.edu.

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
MOLECULAR BASIS OF INHERITED DEAFNESSR01DC002281 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI COREY, DAVID P · 1994 to 2018
$4.4M
FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKSR00DC012534 · NIDCD · OHIO STATE UNIVERSITY · PI SOTOMAYOR, MARCOS · 2013 to 2015
$745k
FORCE SPECTROSCOPY AND STRUCTURAL BIOLOGY OF HAIR-CELL TIP LINKSK99DC012534 · NIDCD · HARVARD MEDICAL SCHOOL · PI SOTOMAYOR, MARCOS · 2012 to 2012
$96k
NICHD NIH HHS P30 HD018655NIDCD NIH HHS K99 DC012534NIDCD NIH HHS K99/R00 DC012534-01NIDCD NIH HHS R00 DC012534NIDCD NIH HHS R01 DC002281NIDCD NIH HHS R01 DC02281
6 · The paper itself

Abstract

Members of the cadherin superfamily of proteins are involved in diverse biological processes such as morphogenesis, sound transduction, and neuronal connectivity. Key to cadherin function is their extracellular domain containing cadherin repeats, which can mediate interactions involved in adhesion and cell signaling. Recent cellular, biochemical, and structural studies have revealed that physical interaction among cadherins is more complex than originally thought. Here we review work on new cadherin complexes and discuss how the classification of the mammalian family can be used to search for additional cadherin-interacting partners. We also highlight some of the challenges in cadherin research; namely, the characterization of a cadherin connectome in biochemical and structural terms, as well as the elucidation of molecular mechanisms underlying the functional diversity of nonclassical cadherins in vivo.

Indexed as

ConnectomeAnimalsBrainCadherinsCell AdhesionCell CommunicationHearingMorphogenesisMultiprotein ComplexesNeuronsSignal TransductionCadherinsMultiprotein Complexesadhesionbrain development.cancerhearingmechanotransductionneuronal connectivity

Identifiers

PMID24794279
PMCPMC4294768

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.