ReviewMolecular neurobiology2015
Cognitive reserve and Alzheimer's disease.
Review in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence.Ageing research reviews · 2022Pooled it
- Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.Brain stimulationTrial
- Associations between life-course cognitive reserve and cognitive domains over 8 years in a large cohort of middle-aged and older adults: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Current status and influencing factors of early delayed neurocognitive recovery in older adult patients after major orthopedic surgery under general anesthesia: a cohort study.Frontiers in public health · 2026Observational
- The Neurogenic Niche: Interactions Among Vessels, Glia, and Neural Stem Cells.Stem cells international · 2026Review
- Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial.JMIR research protocols · 2025Article
- Article
- Clinical, social, molecular, and genetic predictors of cognitive resilience in long-living adults without dementia.Frontiers in dementia · 2025Article
- Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey.Frontiers in aging neuroscience · 2025Article
- Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.Neurobiology of disease · 2024Article
- The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives.Aging and disease · 2024Review
- Charting Alzheimer's Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways.Journal of clinical medicine · 2024Review
- Influence of cognitive reserve on risk of depression and subsequent dementia: A large community-based longitudinal study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Geographic Variation of Prevalence of Alzheimer's Disease and Related Dementias in Central Appalachia.Journal of Alzheimer's disease : JAD · 2024Article
- Design and Harmonization Approach for the Multi-Institutional Neurocognitive Discovery Study (MINDS) of Adult Congenital Heart Disease (ACHD) Neuroimaging Ancillary Study: A Technical Note.Journal of cardiovascular development and disease · 2023Article
- Multisensory Stimulation Reverses Memory Impairment in AdrβInternational journal of molecular sciences · 2023Article
- Interaction betweenGenes · 2023Article
- Cognitive Reserve in Isolated Rapid Eye-Movement Sleep Behavior Disorder.Brain sciences · 2023Article
- Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective.Frontiers in neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD), as a neurodegenerative process caused by widespread senile plaques and neurofibrillary tangles, is faced with an increasingly higher incidence as the global aging develops. Cognitive reserve (CR) hypothesis is proposed to elucidate the disjunction between cognitive performance and the pathological level of AD, positing that some life span experiences will lend protection from AD pathological insults. We provide an overview on recent studies involved in validation of the hypothesis as well as the association between AD and CR proxies, such as educational attainment and quality, occupational activity, leisure activity, general intelligence, and enriched environment. We further discuss some potential mechanisms by which CR proxy acts against AD pathological insults including neuroplasticity, neurogenesis, and locus coeruleus-noradrenergic (LC/NA) system. Finally, we review the applications of CR theory for AD prevention and therapy, particularly through physical activity and cognitive training strategy. We believe that a better knowledge of the relationship between AD and CR, accompanied by a successful transition of research accomplishments into practice, will impart much relief to individuals suffering from AD.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.