ArticleMolecular neurobiology2015
Neurochemical properties of the synapses between the parabrachial nucleus-derived CGRP-positive axonal terminals and the GABAergic neurons in the lateral capsular division of central nucleus of amygdala.
Article in Molecular neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Calcitonin Gene-Related Peptide (CGRP)-Containing Terminals in the Central Amygdala of Mice and Monkeys: Ultrastructural Analysis and Subsynaptic Expression of GluD1.The European journal of neuroscience · 2026Article
- Temporal regulation of macrophage polarization by abnormally innervated CGRP + Sensory nerves following spinal cord injury.Cellular and molecular life sciences : CMLS · 2026Review
- Therapeutic Effects of Phytoestrogen Naringenin in Polycystic Ovary Syndrome (PCOS): Involvement of Kisspeptin and Calcitonin Gene Related Peptide Signalling Pathways.Reports of biochemistry & molecular biology · 2025Article
- Sex Differences in Central Amygdala Glutamate Responses to Calcitonin Gene-Related Peptide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Sex differences in central amygdala glutamate responses to calcitonin gene-related peptide.bioRxiv : the preprint server for biology · 2024Article
- Divergent input patterns to the central lateral amygdala play a duet in fear memory formation.iScience · 2024Article
- Cells and circuits for amygdala neuroplasticity in the transition to chronic pain.Cell reports · 2024Article
- CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond.Physiological reviews · 2023Review
- Sex Differences in CGRP Regulation and Function in the Amygdala in a Rat Model of Neuropathic Pain.Frontiers in molecular neuroscience · 2022Article
- Left and right hemispheric lateralization of the amygdala in pain.Progress in neurobiology · 2021Review
- A Neural Circuit from Thalamic Paraventricular Nucleus to Central Amygdala for the Facilitation of Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Why does stress aggravate itch? A possible role of the amygdala.Experimental dermatology · 2019Article
- Sweet and bitter taste stimuli activate VTA projection neurons in the parabrachial nucleus.Brain research · 2019Article
- Collateral Projections from the Lateral Parabrachial Nucleus to the Central Amygdaloid Nucleus and the Ventral Tegmental Area in the Rat.Anatomical record (Hoboken, N.J. : 2007) · 2019Article
- A Subpopulation of Amygdala Neurons Mediates the Affective Component of Itch.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Valence coding in amygdala circuits.Current opinion in behavioral sciences · 2019Article
- Defining circuit-specific roles for G protein-coupled receptors in aversive learning.Current opinion in behavioral sciences · 2019Article
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.Trends in neurosciences · 2018Review
- Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain.Biological psychiatry · 2017Article
- Cyclic GMP-dependent protein kinase-I localized in nociceptors modulates nociceptive cortical neuronal activity and pain hypersensitivity.Molecular pain · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lateral capsular division of central nucleus of amygdala (CeC) contains neurons using γ-amino butyric acid (GABA) as the predominant neurotransmitter and expresses abundant calcitonin gene-related peptide (CGRP)-positive terminals. However, the relationship between them has not been revealed yet. Using GAD67-green fluorescent protein (GFP) knock-in mouse, we investigated the neurochemical features of synapses between CGRP-positive terminals and GABAergic neurons within CeC and the potential involvement of CGRP1 receptor by combining fluorescent in situ hybridization for CGRP1 receptor mRNA with immunofluorescent histochemistry for GFP and CGRP. The ultrastructures of these synapses were investigated with pre-embedding electron microscopy for GFP and CGRP. We found that some GABAergic neurons in the CeC received parabrachial nucleus (PBN) derived CGRP innervations and some of these GABAergic neurons can be activated by subcutaneous injection of formalin. Moreover, more than 90 % GABAergic neurons innervated by CGRP-positive terminal also express CGRP1 receptor mRNA. The CGRP-positive fibers made symmetric synapses onto the GABAergic somata, and asymmetric synapses onto the GABA-LI dendritic shafts and spines. This study provides direct ultrastructural evidences for the synaptic contacts between CGRP-positive terminals and GABAergic neurons within the CeC, which may underlie the pain-related neural pathway from PBN to CeC and be involved in the chronic pain modulation.
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