ArticleJournal of the American College of Cardiology2014
Rotor stability separates sustained ventricular fibrillation from self-terminating episodes in humans.
Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- Complexity analysis of electrical activity during endocardial and epicardial biventricular mapping of ventricular fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Dispersion of Activation in Single-Beat Global Maps During Programmed Ventricular Stimulation Identifies Infarct-Related Ventricular Tachycardia Isthmus Sites.Journal of the American Heart Association · 2024Article
- Trigger and Substrate Mapping and Ablation for Ventricular Fibrillation in the Structurally Normal Heart.Journal of cardiovascular development and disease · 2023Review
- Different Ventricular Fibrillation Types in Low-Dimensional Latent Spaces.Sensors (Basel, Switzerland) · 2023Article
- Distinct spectral dynamics of implanted cardiac defibrillator signals in spontaneous termination of polymorphic ventricular tachycardia and fibrillation in patients with electrical and structural diseases.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022Article
- Direct observation of a stable spiral wave reentry in ventricles of a whole human heart using optical mapping for voltage and calcium.Heart rhythm · 2022Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- High-resolution mapping and successful ablation of Purkinje ectopy-triggered ventricular fibrillation storm.HeartRhythm case reports · 2022Article
- Electrical Substrate Ablation for Refractory Ventricular Fibrillation: Results of the AVATAR Study.Circulation. Arrhythmia and electrophysiology · 2021Article
- Mapping Technologies for Catheter Ablation of Atrial Fibrillation Beyond Pulmonary Vein Isolation.European cardiology · 2021Review
- Phase Entrainment of Induced Ventricular Fibrillation: A Human Feasibility and Proof of Concept Study.Journal of atrial fibrillation · 2019Article
- New Concepts in Sudden Cardiac Arrest to Address an Intractable Epidemic: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2019Review
- Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern.PLoS computational biology · 2018Article
- Analytical approaches for myocardial fibrillation signals.Computers in biology and medicine · 2018Review
- Statistical guidance of VT ablation.Journal of cardiovascular electrophysiology · 2018Article
- Ablation Approaches for Ventricular Fibrillation.Current treatment options in cardiovascular medicine · 2018Review
- Characterizing Electrogram Signal Fidelity and the Effects of Signal Contamination on Mapping Human Persistent Atrial Fibrillation.Frontiers in physiology · 2018Article
- Spatiotemporal Progression of Early Human Ventricular Fibrillation.JACC. Clinical electrophysiology · 2017Article
- Rotors exhibit greater surface ECG variation during ventricular fibrillation than focal sources due to wavebreak, secondary rotors, and meander.Journal of cardiovascular electrophysiology · 2017Article
- Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThis study mapped human ventricular fibrillation (VF) to define mechanistic differences between episodes requiring defibrillation versus those that spontaneously terminate.
backgroundVF is a leading cause of mortality; yet, episodes may also self-terminate. We hypothesized that the initial maintenance of human VF is dependent upon the formation and stability of VF rotors.
methodsWe enrolled 26 consecutive patients (age 64 ± 10 years, n = 13 with left ventricular dysfunction) during ablation procedures for ventricular arrhythmias, using 64-electrode basket catheters in both ventricles to map VF prior to prompt defibrillation per the institutional review board-approved protocol. A total of 52 inductions were attempted, and 36 VF episodes were observed. Phase analysis was applied to identify biventricular rotors in the first 10 s or until VF terminated, whichever came first (11.4 ± 2.9 s to defibrillator charging).
resultsRotors were present in 16 of 19 patients with VF and in all patients with sustained VF. Sustained, but not self-limiting VF, was characterized by greater rotor stability: 1) rotors were present in 68 ± 17% of cycles in sustained VF versus 11 ± 18% of cycles in self-limiting VF (p < 0.001); and 2) maximum continuous rotations were greater in sustained (17 ± 11, range 7 to 48) versus self-limiting VF (1.1 ± 1.4, range 0 to 4, p < 0.001). Additionally, biventricular rotor locations in sustained VF were conserved across multiple inductions (7 of 7 patients, p = 0.025).
conclusionsIn patients with and without structural heart disease, the formation of stable rotors identifies individuals whose VF requires defibrillation from those in whom VF spontaneously self-terminates. Future work should define the mechanisms that stabilize rotors and evaluate whether rotor modulation may reduce subsequent VF risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.