ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
The global burden of disease for skin, lung, and bladder cancer caused by arsenic in food.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Potential Co-exposure to Arsenic and Fluoride and Biomonitoring Equivalents for Mexican Children.Annals of global health · 2018Pooled it
- Pooled it
- Arsenic content and exposure in brown rice compared to white rice in the United States.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- Alpha-lipoic acid, as an effective agent against toxic elements: a review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Arsenic disrupts H3K9me3 and H3K27me3 balance by biasing PRC2.1 and PRC2.2 activity via PALI1 inhibition in carcinogenesis.International journal of biological sciences · 2025Article
- Leveraging the One Health concept for arsenic sustainability.Eco-Environment & Health · 2024Review
- Unintended food safety impacts of agricultural circular economies, with case studies in arsenic and mycotoxins.NPJ science of food · 2024Article
- Guidance on risk-benefit assessment of foods.EFSA journal. European Food Safety Authority · 2024Article
- Epidemiology, Pattern, and Survival of Multiple Primary Malignant Neoplasms in Southeast Iran: Results of Kerman Population-Based Cancer Registry 2014-2020.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Epigenomic reprogramming in iAs-mediated carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Arsenic and cancer: Evidence and mechanisms.Advances in pharmacology (San Diego, Calif.) · 2023Article
- PIN1-mediated ROS production is involved in antagonism of N-acetyl-L-cysteine against arsenic-induced hepatotoxicity.Toxicology research · 2022Article
- Natural Dietary Compounds in the Treatment of Arsenic Toxicity.Molecules (Basel, Switzerland) · 2022Review
- Exposure to Toxic Metals and Health Risk Assessment through Ingestion of Canned Sardines Sold in Brazil.International journal of environmental research and public health · 2022Article
- Alpha-2 Heremans Schmid Glycoprotein (AHSG) promotes the proliferation of bladder cancer cells by regulating the TGF-β signalling pathway.Bioengineered · 2022Article
- Burden of Coronary Heart Disease and Cancer from Dietary Exposure to Inorganic Arsenic in Adults in China, 2016.Annals of global health · 2022Article
- Heavy Metal Accumulation in Rice and Aquatic Plants Used as Human Food: A General Review.Toxics · 2021Review
- High Concentration of Heavy Metal and Metalloid Levels in EdibleInternational journal of environmental research and public health · 2021Article
- Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study.BMC medicine · 2021Article
- Association between rice consumption and risk of cancer incidence in the California Teachers Study.Cancer causes & control : CCC · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundArsenic is a ubiquitous, naturally occurring metalloid that poses a significant human cancer risk. While water consumption provides the majority of human exposure, millions of individuals worldwide are significantly exposed to arsenic through naturally occurring levels of arsenic in grains, vegetables, meats and fish, as well as through food processed with water containing arsenic. Thus, we estimated the global burdens of disease for bladder, lung, and skin cancers attributable to inorganic arsenic in food.
methodsTo determine foodborne inorganic arsenic exposures worldwide, we used World Health Organization estimates of food consumption in thirteen country clusters, in conjunction with reported measurements of total and inorganic arsenic in different foods. We estimated slope factors for arsenic-related bladder and lung cancers, and used the U.S. Environmental Protection Agency skin cancer slope factor, to calculate the annual risk of the cancer incidence in males and females within each country cluster.
resultsWe estimated that each year 9,129 to 119,176 additional cases of bladder cancer, 11,844 to 121,442 of lung cancer, and 10,729 to 110,015 of skin cancer worldwide are attributable to inorganic arsenic in food.
conclusionsThese estimates indicate that foodborne arsenic exposure causes a significant global burden of human disease. IMPACT: Estimating the global cancer burden caused by arsenic exposure in food will support policies that reduce exposure to disease-promoting environmental hazards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.