Trial reportVaccine2014
Cluster randomized trial of a toolkit and early vaccine delivery to improve childhood influenza vaccination rates in primary care.
Trial report in Vaccine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01664793 (From Innovation to Solutions), which is not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
From Innovation to Solutions: Autodialers, Use of Early Autumn Physicals and Vaccination Assessment as a Vital Sign to Increase Childhood Influenza Vaccination in Diverse Settings
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Audit and feedback: effects on professional practice.The Cochrane database of systematic reviews · 2025Pooled it
- Pooled it
- Spread tools: a systematic review of components, uptake, and effectiveness of quality improvement toolkits.Implementation science : IS · 2019Pooled it
- Face-to-face interventions for informing or educating parents about early childhood vaccination.The Cochrane database of systematic reviews · 2018Pooled it
- Interventions to reduce inequalities in vaccine uptake in children and adolescents aged <19 years: a systematic review.Journal of epidemiology and community health · 2017Pooled it
- Cost-Effectiveness of the 4 Pillars Practice Transformation Program to Improve Vaccination of Adults Aged 65 and Older.Journal of the American Geriatrics Society · 2017Trial
- Increasing childhood influenza vaccination: a cluster randomized trial.American journal of preventive medicine · 2014Trial
- Maintenance of Increased Childhood Influenza Vaccination Rates 1 Year After an Intervention in Primary Care Practices.Academic pediatricsTrial
- Development and Evaluation of an HPV Vaccine Champion Training: a Strategy to Boost Adolescent Vaccination in Community Health Centers in Florida.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Article
- Vaccination in infected children: a qualitative study of clinical decision-making.Primary health care research & development · 2026Article
- Primary care pediatricians' involvement in influenza vaccination campaign in Italy.Italian journal of pediatrics · 2025Article
- Digital Gamification Tool (Let's Control Flu) to Increase Vaccination Coverage Rates: Proposal for Algorithm Development.JMIR research protocols · 2024Article
- Clinician perspectives on strategies to improve patient maternal immunization acceptability in obstetrics and gynecology practice settings.Human vaccines & immunotherapeutics · 2018Article
- Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic.Vaccine · 2018Article
- Cost-effectiveness of increasing vaccination in high-risk adults aged 18-64 Years: a model-based decision analysis.BMC infectious diseases · 2018Article
- Interventions to increase pediatric vaccine uptake: An overview of recent findings.Human vaccines & immunotherapeutics · 2017Review
- Kansas Provider Report of Adolescent Vaccinations in Their Practice.Kansas journal of medicine · 2017Article
- Cost effectiveness of a practice-based intervention to improve vaccination rates in adults less than 65-years-old.Human vaccines & immunotherapeutics · 2017Article
- Reducing Racial Disparities in Influenza Vaccination Among Children With Asthma.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo increase childhood influenza vaccination rates using a toolkit and early vaccine delivery in a randomized cluster trial.
methodsTwenty primary care practices treating children (range for n=536-8183) were randomly assigned to Intervention and Control arms to test the effectiveness of an evidence-based practice improvement toolkit (4 Pillars Toolkit) and early vaccine supplies for use among disadvantaged children on influenza vaccination rates among children 6 months-18 years. Follow-up staff meetings and surveys were used to assess use and acceptability of the intervention strategies in the Intervention arm. Rates for the 2010-2011 and 2011-2012 influenza seasons were compared. Two-level generalized linear mixed modeling was used to evaluate outcomes.
resultsOverall increases in influenza vaccination rates were significantly greater in the Intervention arm (7.9 percentage points) compared with the Control arm (4.4 percentage points; P<0.034). These rate changes represent 4522 additional doses in the Intervention arm vs. 1390 additional doses in the Control arm. This effect of the intervention was observed despite the fact that rates increased significantly in both arms - 8/10 Intervention (all P<0.001) and 7/10 Control sites (P-values=0.04 to <0.001). Rates in two Intervention sites with pre-intervention vaccination rates >58% did not significantly increase. In regression analyses, a child's likelihood of being vaccinated was significantly higher with: younger age, white race (Odds ratio [OR]=1.29; 95% confidence interval [CI]=1.23-1.34), having commercial insurance (OR=1.30; 95%CI=1.25-1.35), higher pre-intervention practice vaccination rate (OR=1.25; 95%CI=1.16-1.34), and being in the Intervention arm (OR=1.23; 95%CI=1.01-1.50). Early delivery of influenza vaccine was rated by Intervention practices as an effective strategy for raising rates.
conclusionsImplementation of a multi-strategy toolkit and early vaccine supplies can significantly improve influenza vaccination rates among children in primary care practices but the effect may be less pronounced in practices with moderate to high existing vaccination rates. Clinical trial registry name/number: From Innovation to Solutions: Childhood Influenza/NCT01664793.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.