Evidence map›Paper›PMID 24793909›Full record

Trial reportPain2014

Short-term improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with comorbid osteoarthritis and insomnia.

Michael V Vitiello, Susan M McCurry, Susan M Shortreed, Laura D Baker, Bruce D Rybarczyk, Francis J Keefe, Michael Von Korff

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01142349 (Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults), which is not on this map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01142349 nacompletednot on this map

Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older Adults

TypeinterventionalSponsorUniversity of WashingtonRan2009 to 2013Enrolled367ConditionsPain Dysfunction, Sleep Disturbance, OsteoarthritisArmsLifestyles A, Lifestyles B, Lifestyles C
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael V VitielloDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA Department of Psychosocial and Community Health, University of Washington School of Nursing, Seattle, WA, USA Group Health Research Institute, Seattle, WA, USA Department of Internal Medicine and Epidemiology, Wake Forest University School of Medicine, Winston-Salem, NC, USA Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA Duke University Medical Center, Durham, NC, USA.
Susan M McCurry
Susan M Shortreed
Laura D Baker
Bruce D Rybarczyk
Francis J Keefe
Michael Von Korff

Funding

Cognitive Behavioral Therapy for Arthritis Pain and Insomnia in Older AdultsR01AG031126 · NIA · UNIVERSITY OF WASHINGTON · PI MCCURRY, SUSAN M, VITIELLO, MICHAEL V. · 2008 to 2012
$3.6M
NIA NIH HHS R01 AG031126NIA NIH HHS R01-AG031126
6 · The paper itself

Abstract

unlabelledIn a primary care population of 367 older adults (aged ⩾60 years) with osteoarthritis (OA) pain and insomnia, we examined the relationship between short-term improvement in sleep and long-term sleep, pain, and fatigue outcomes through secondary analyses of randomized controlled trial data. Study participants, regardless of experimental treatment received, were classified either as improvers (⩾30% baseline to 2-month reduction on the Insomnia Severity Index [ISI]) or as nonimprovers. After controlling for treatment arm and potential confounders, improvers showed significant, sustained improvements across 18 months compared with nonimprovers in pain severity (P<0.001, adjusted mean difference=-0.51 [95% CI: -0.80, -0.21), arthritis symptoms (P<0.001, 0.63 [0.26, 1.00]), and fear avoidance (P=0.009, -2.27 [-3.95, -0.58]) but not in catastrophizing or depression. Improvers also showed significant, sustained improvements in ISI (P<0.001, -3.03 [-3.74, -2.32]), Pittsburgh Sleep Quality Index Total (P<0.001, -1.45 [-1.97, -0.93]) and general sleep quality (P<0.001, -0.28 [-0.39, -0.16]) scores, Flinders Fatigue Scale (P<0.001, -1.99 [-3.01, -0.98]), and Dysfunctional Beliefs About Sleep Scale (P=0.037, -2.44 [-4.74, -0.15]), but no improvements on the Functional Outcomes of Sleep Questionnaire or the Epworth Sleepiness Scale. We conclude that short-term (2-month) improvements in sleep predicted long-term (9- and 18-month) improvements for multiple measures of sleep, chronic pain, and fatigue. These improvements were not attributable to nonspecific benefits for psychological well-being, such as reduced depression. These findings are consistent with benefits of improved sleep for chronic pain and fatigue among older persons with osteoarthritis pain and comorbid insomnia if robust improvements in sleep are achieved and sustained.

trial registrationClinicalTrials.gov Identifier: NCT01142349.

Indexed as

AgedAged, 80 and overAttentionCognitive Behavioral TherapyFatigueFemaleHumansMaleMiddle AgedOsteoarthritisPainSleepSleep Initiation and Maintenance DisordersTreatment OutcomeAgingCognitive behavioral therapyFatigueInsomniaOsteoarthritisPainSleep

Identifiers

PMID24793909
PMCPMC4104256

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.