ArticleAnnals of biomedical engineering2014
An in vivo rat model of artery buckling for studying wall remodeling.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Automated segmentation and quantitative analysis of vascular curvature features in unruptured intracranial aneurysms based on time-of-flight magnetic resonance angiography (TOF-MRA).Quantitative imaging in medicine and surgery · 2026Article
- Modified Intracranial Aneurysm Rupture Rat Model with Angiographic Imaging.Translational stroke research · 2025Article
- Imaging Cerebral Arteries Tortuosity and Velocities by Transcranial Doppler Ultrasound Is a Reliable Assessment of Brain Aneurysm in Mouse Models.Stroke (Hoboken, N.J.) · 2023Article
- Buckling of Arteries With Noncircular Cross Sections: Theory and Finite Element Simulations.Frontiers in physiology · 2021Article
- Computational simulations of the helical buckling behavior of blood vessels.International journal for numerical methods in biomedical engineering · 2019Article
- Increased tortuosity of ACA might be associated with increased risk of ACoA aneurysm development and less aneurysm dome size: a computer-aided analysis.European radiology · 2019Article
- Tortuosity of the Internal Carotid Artery and Its Clinical Significance in the Development of Aneurysms.Journal of clinical medicine · 2019Article
- Arterial wall remodeling under sustained axial twisting in rats.Journal of biomechanics · 2017Article
- Buckling Reduces eNOS Production and Stimulates Extracellular Matrix Remodeling in Arteries in Organ Culture.Annals of biomedical engineering · 2016Article
- Artery buckling analysis using a two-layered wall model with collagen dispersion.Journal of the mechanical behavior of biomedical materials · 2016Article
- Critical buckling pressure in mouse carotid arteries with altered elastic fibers.Journal of the mechanical behavior of biomedical materials · 2015Article
- Mechanical instability of normal and aneurysmal arteries.Journal of biomechanics · 2014Article
- Artery buckling stimulates cell proliferation and NF-κB signaling.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Theoretical modeling and in vitro experiments have demonstrated that arterial buckling is a possible mechanism for the development of artery tortuosity. However, there has been no report of whether artery buckling develops into tortuosity, partially due to the lack of in vivo models for long-term studies. The objective of this study was to establish an in vivo buckling model in rat carotid arteries for studying arterial wall remodeling after buckling. Rat left carotid arteries were transplanted to the right carotid arteries to generate buckling under in vivo pressure and were maintained for 1 week to examine wall remodeling and adaptation. Our results showed that a significant buckling was achieved in the carotid arterial grafts with altered wall stress. Cell proliferation and matrix metalloprotinease-2 (MMP-2) expression in the buckled arteries increased significantly compared with the controls. The tortuosity level of the grafts also slightly increased 1 week post-surgery, while there was no change in vessel dimensions, blood pressure, and blood flow velocity. The artery buckling model provides a useful tool for further study of the adaptation of arteries into tortuous shapes.
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