ArticleEuropean journal of nutrition2015
High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort.
Article in European journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation.European journal of nutrition · 2017Trial
- Micronutrient intake and telomere length: findings from the UK Biobank.European journal of nutrition · 2024Article
- Article
- Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis.Frontiers in cardiovascular medicine · 2022Review
- Preconception telomere length as a novel maternal biomarker to assess the risk of spina bifida in the offspring.Birth defects research · 2020Article
- Telomere length and associated factors in older adults with hypertension.The Journal of international medical research · 2019Review
- Serum and Dietary Folate and Vitamin BOxidative medicine and cellular longevity · 2019Article
- Article
- Serum Folate, Vitamin B-12, Vitamin A, γ-Tocopherol, α-Tocopherol, and Carotenoids Do Not Modify Associations between Cadmium Exposure and Leukocyte Telomere Length in the General US Adult Population.The Journal of nutrition · 2017Article
- Increased Telomere Attrition After Renal Transplantation-Impact of Antimetabolite Therapy.Transplantation direct · 2016Article
- Prospective study of telomere length and LINE-1 methylation in peripheral blood cells: the role of B vitamins supplementation.European journal of nutrition · 2016Article
- The relationship between peripheral blood mononuclear cells telomere length and diet - unexpected effect of red meat.Nutrition journal · 2016Observational
- Leukocyte Telomere Length is Associated With Serum Vitamin B12 and Homocysteine Levels in Older Adults With the Presence of Systemic Inflammation.Clinical nutrition research · 2016Article
- Association between dietary folate intake and severe abdominal aorta calcification in adults: A cross-sectional analysis of the national health and nutrition examination survey.Diabetes & vascular disease researchArticle
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Authors and funding
7 authors.
Funding
Abstract
purposeShortening of telomeres, the protective structures at the ends of eukaryotic chromosomes, is associated with age-related pathologies. Telomere length is influenced by DNA integrity and DNA and histone methylation. Folate plays a role in providing precursors for nucleotides and methyl groups for methylation reactions and has the potential to influence telomere length.
methodWe determined the association between leukocyte telomere length and long-term plasma folate status (mean of 4 years) in Framingham Offspring Study (n = 1,044, females = 52.1 %, mean age 59 years) using data from samples collected before and after folic acid fortification. Leukocyte telomere length was determined by Southern analysis and fasting plasma folate concentration using microbiological assay.
resultsThere was no significant positive association between long-term plasma folate and leukocyte telomere length among the Framingham Offspring Study participants perhaps due to their adequate folate status. While the leukocyte telomere length in the second quintile of plasma folate was longer than that in the first quintile, the difference was not statistically significant. The leukocyte telomere length of the individuals in the fifth quintile of plasma folate was shorter than that of those in the second quintile by 180 bp (P < 0.01). There was a linear decrease in leukocyte telomere length with higher plasma folate concentrations in the upper four quintiles of plasma folate (P for trend = 0.001). Multivitamin use was associated with shorter telomeres in this cohort (P = 0.015).
conclusionsHigh plasma folate status possibly resulting from high folic acid intake may interfere with the role of folate in maintaining telomere integrity.
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