ArticleGenetics2014
Pleiotropic mutations are subject to strong stabilizing selection.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Stabilizing and directional selection shape the genetic variation of gene expression in the transcriptome of Chlamydomonas.Molecular biology and evolution · 2026Article
- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- What Has SARS-CoV-2 Taught Us About Evolution?Cureus · 2025Review
- Detecting natural selection in trait-trait coevolution.BMC ecology and evolution · 2023Article
- Weaker selection on genes with treatment-specific expression consistent with a limit on plasticity evolution in Arabidopsis thaliana.Genetics · 2023Article
- Alternative telomere maintenance mechanism iniScience · 2023Article
- Cooperation loci are more pleiotropic than private loci in the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- The contribution of mutation and selection to multivariate quantitative genetic variance in an outbred population ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular evolution of bumble bee vitellogenin and vitellogenin-like genes.Ecology and evolution · 2021Article
- Correlational selection in the age of genomics.Nature ecology & evolution · 2021Review
- Maintenance of Complex Trait Variation: Classic Theory and Modern Data.Frontiers in genetics · 2021Review
- Fly wing evolution explained by a neutral model with mutational pleiotropy.Evolution; international journal of organic evolution · 2020Article
- Genetic basis for divergence in developmental gene expression in two closely related sea urchins.Nature ecology & evolution · 2020Article
- Why does allometry evolve so slowly?Integrative and comparative biology · 2019Article
- Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.Molecular biology and evolution · 2019Article
- Genetic constraints on microevolutionary divergence of sex-biased gene expression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Mutational Pleiotropy and the Strength of Stabilizing Selection Within and Between Functional Modules of Gene Expression.Genetics · 2018Article
- Structure of the Transcriptional Regulatory Network Correlates with Regulatory Divergence in Drosophila.Molecular biology and evolution · 2017Article
- The Relationship between Selection, Network Connectivity, and Regulatory Variation within a Population of Capsella grandiflora.Genome biology and evolution · 2017Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The assumption that pleiotropic mutations are more deleterious than mutations with more restricted phenotypic effects is an important premise in models of evolution. However, empirical evidence supporting this assumption is limited. Here, we estimated the strength of stabilizing selection on mutations affecting gene expression in male Drosophila serrata. We estimated the mutational variance (VM) and the standing genetic variance (VG) from two well-matched panels of inbred lines: a panel of mutation accumulation (MA) lines derived from a single inbred ancestral line and a panel of inbred lines derived from an outbred population. For 855 gene-expression traits, we estimated the strength of stabilizing selection as s = VM/VG. Selection was observed to be relatively strong, with 17% of traits having s > 0.02, a magnitude typically associated with life-history traits. Randomly assigning expression traits to five-trait sets, we used factor analytic mixed modeling in the MA data set to identify covarying traits that shared pleiotropic mutations. By assigning traits to the same trait sets in the outbred line data set, we then estimated s for the combination of traits affected by pleiotropic mutation. For these pleiotropic combinations, the median s was three times greater than s acting on the individual component traits, and 46% of the pleiotropic trait combinations had s > 0.02. Although our analytical approach was biased toward detecting mutations with relatively large effects, likely overestimating the average strength of selection, our results provide widespread support for the prediction that stronger selection can act against mutations with pleiotropic effects.
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