Evidence map›Paper›PMID 24793097›Full record

ArticleVeterinary microbiology2014

Feline fecal virome reveals novel and prevalent enteric viruses.

Terry Fei Fan Ng, João Rodrigo Mesquita, Maria São José Nascimento, Nikola O Kondov, Walt Wong, Gábor Reuter, Nick J Knowles, Everardo Vega, Mathew D Esona, Xutao Deng and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Terry Fei Fan NgBlood Systems Research Institute, San Francisco, San Francisco, CA, USA; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA.
João Rodrigo MesquitaDepartment of Animal Science, Rural Engineering and Veterinary, Polytechnic Institut of Viseu, Viseu, Portugal.
Maria São José NascimentoDepartment of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Nikola O KondovBlood Systems Research Institute, San Francisco, San Francisco, CA, USA.
Walt WongBlood Systems Research Institute, San Francisco, San Francisco, CA, USA.
Gábor ReuterRegional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Pécs, Hungary.
Nick J KnowlesThe Pirbright Institute, Woking, Surrey, United Kingdom.
Everardo VegaNCIRD, National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Mathew D EsonaGRVLB, Rotavirus Surveillance, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Xutao DengBlood Systems Research Institute, San Francisco, San Francisco, CA, USA; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA.
Jan VinjéNCIRD, National Calicivirus Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Eric DelwartBlood Systems Research Institute, San Francisco, San Francisco, CA, USA; Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA, USA. Electronic address: delwarte@medicine.ucsf.edu.
Blood Systems Research Institute · USNational Center for Immunization and Respiratory Diseases · USCenters for Disease Control and Prevention · USNational Public Health and Medical Officer Service · HUPolytechnic Institute of Viseu · PTThe Pirbright Institute · GBUniversidade do Porto · PT

Funding

Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
Biotechnology and Biological Sciences Research CouncilNHLBI NIH HHS HL105770NHLBI NIH HHS R01 HL105770
6 · The paper itself

Abstract

Humans keep more than 80 million cats worldwide, ensuring frequent exposure to their viruses. Despite such interactions the enteric virome of cats remains poorly understood. We analyzed a fecal sample from a single healthy cat from Portugal using viral metagenomics and detected five eukaryotic viral genomes. These viruses included a novel picornavirus (proposed genus "Sakobuvirus") and bocavirus (feline bocavirus 2), a variant of feline astrovirus 2 and sequence fragments of a highly divergent feline rotavirus and picobirnavirus. Feline sakobuvirus A represents the prototype species of a proposed new genus in the Picornaviridae family, distantly related to human salivirus and kobuvirus. Feline astroviruses (mamastrovirus 2) are the closest known relatives of the classic human astroviruses (mamastrovirus 1), suggestive of past cross-species transmission. Presence of these viruses by PCR among Portuguese cats was detected in 13% (rotavirus), 7% (astrovirus), 6% (bocavirus), 4% (sakobuvirus), and 4% (picobirnavirus) of 55 feline fecal samples. Co-infections were frequent with 40% (4/10) of infected cats shedding more than one of these five viruses. Our study provides an initial description of the feline fecal virome indicating a high level of asymptomatic infections. Availability of the genome sequences of these viruses will facilitate future tropism and feline disease association studies.

Indexed as

AnimalsCatsFecesGenome, ViralMetagenomicsMolecular Sequence DataPhylogenyPortugalRNA, ViralVirusesRNA, ViralEnteric virusFelis catusMetagenomicsSakobuvirusVirome

Identifiers

PMID24793097
PMCPMC4080910
OpenAlexW2112917912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.