ArticleJournal of assisted reproduction and genetics2014
CYP11A1 microsatellite (tttta)n polymorphism in PCOS women from South India.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Genetic exploration of the impact of CYP11A1 polymorphisms on the development of PCOS: evidence from a meta-analysis with trial sequential analysis.Scientific reports · 2026Pooled it
- A Review of microRNAs in the Post-transcriptional Regulation and its Clinical Manifestation in the Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Developmental and functional landscape of theca cells in ovarian biology.Biological research · 2026Review
- Diagnostic Criteria and Genetic Basis of Polycystic Ovary Syndrome: A Narrative Review.Metabolites · 2026Review
- Genomic association of SNPs rs4077582 of CYP11A1 and rs700519 of CYP19A1 genes with polycystic ovarian syndrome.Endocrine · 2025Article
- Vitamin D in Melanoma: Potential Role of Cytochrome P450 Enzymes.Life (Basel, Switzerland) · 2024Review
- A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).Journal of assisted reproduction and genetics · 2022Review
- Article
- Polycystic Ovary Syndrome: the Epigenetics Behind the Disease.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- A Review onGenes · 2022Review
- The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis.Journal of ovarian research · 2021Review
- Role of Lipid Metabolism and Signaling in Mammalian Oocyte Maturation, Quality, and Acquisition of Competence.Frontiers in cell and developmental biology · 2021Review
- Identifying genes associated with the development of human polycystic ovary syndrome.Saudi journal of biological sciences · 2020Review
- Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India.The Indian journal of medical research · 2019Review
- Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article.European journal of obstetrics & gynecology and reproductive biology: X · 2019Review
- Pathophysiological mechanisms of gonadotropins- and steroid hormones-related genes in etiology of polycystic ovary syndrome.Iranian journal of basic medical sciences · 2019Review
- Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology.Genetics research international · 2018Review
- An update on polycystic ovary syndrome: A review of the current state of knowledge in diagnosis, genetic etiology, and emerging treatment options.Women's health (London, England)Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolycystic ovary syndrome (PCOS) is a condition with central feature of hyperandrogensism that affects 5-12 % of women worldwide. P450sec the cholesterol side chain cleavage enzyme encoded by CYP11A1 gene is instrumental in the synthesis of sex hormones. A promoter pentanucleotide repeat (tttta)(n) polymorphism of this gene is reported to be associated with several hormone related diseases including PCOS. Here we aimed to examine the involvement of CYP11A1 polymorphism with PCOS susceptibility in a case-control study conducted among South Indian women.
methodsA total of 542 subjects comprised of 267 PCOS patients and 275 controls were recruited. DNA was extracted from blood and CYP11A1 (tttta)(n) polymorphism was genotyped by PCR-PAGE.
resultsFifteen different alleles ranging between 2-16 repeats were identified in the studied group and the most frequent allele observed in controls was of 8 repeats. The presence of >8 repeat allele was common in patients (64 % vs. 38 %) and showed a three-fold risk for PCOS susceptibility than controls (OR = 2.93; p < 0.05). PCOS women with higher BMI were markedly elevated in early quartile (p < 0.05).
conclusionCYP11A1 (tttta)(n) repeat polymorphism appeared to be a potential molecular marker for PCOS risk in our population. Gene-gene and gene-environmental interactions with respect to obesity may play a role in the early onset of this multifactorial condition. This is the first report from South India; however, replicative studies considering other probable causative factors for PCOS risk are warranted.
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