ArticleCell2014
Tissue-specific signals control reversible program of localization and functional polarization of macrophages.
Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 523 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
523 citing papers in PubMed, 868 citations in OpenAlex.
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- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- CYTOKINE SIGNALING REGULATES MULTIPLE STAGES OF GAMMA-HERPESVIRUS INFECTION IN MYELOID CELLS.bioRxiv : the preprint server for biology · 2026Article
- GALNT6-glycosylated LRG1 mediates the interaction between M2 macrophages and pancreatic cancer cells by activating CCR1/PI3K/AKT axis.Molecular and cellular biochemistry · 2026Article
- Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.Science immunology · 2026Article
- Myeloid GHSR Deficiency Protects Against Endotoxemia via Macrophage Mitochondrial Reprogramming.Biomedicines · 2026Article
- GATA6 marks fibrosis-associated stromal cells rather than repair macrophages in kidney disease.Scientific reports · 2026Article
- Mesenteric macrophage-monocyte circuit controls systemic inflammation during enteric bacterial infection.The Journal of experimental medicine · 2026Article
- Molecular and immunohistochemical characterization of intestinal macrophages subsets in goldfish.Scientific reports · 2026Article
- Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin.The Journal of clinical investigation · 2026Article
- FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages.Cell reports · 2026Article
- Melanoma exosomal miR-708-5p promotes macrophage M2 polarization and cancer metastasis.Cell death & disease · 2026Article
- Tissue signatures of human macrophages during homeostasis and activation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- SFTSV: a priority pathogen in need of a cure-reviewing the therapeutic.Archives of microbiology · 2026Review
- The oligogenic inheritance test GCOD detects risk genes and their interactions in congenital heart defects.Genome research · 2026Article
- Enteric nervous system and inflammatory bowel disease.Gastroenterology report · 2026Review
- 4D-printed Fe3O4-PLLA scaffolds modulate osteoimmune microenvironment for oral bone repair.Materials today. Bio · 2026Article
- Dietary fiber deficiency exacerbates intestinal inflammation via miR-6240-enriched gut extracellular vesicles.NPJ biofilms and microbiomes · 2026Article
- An EGR1-dependent cascade modulates genome architecture at the CSF1R locus.Nucleic acids research · 2026Article
- Macrophage states and immunometabolic adaptation in peritoneal metastases from colorectal cancer.Frontiers in immunology · 2026Review
463 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue-resident macrophages are highly heterogeneous in terms of their functions and phenotypes as a consequence of adaptation to different tissue environments. Local tissue-derived signals are thought to control functional polarization of resident macrophages; however, the identity of these signals remains largely unknown. It is also unknown whether functional heterogeneity is a result of irreversible lineage-specific differentiation or a consequence of continuous but reversible induction of diverse functional programs. Here, we identified retinoic acid as a signal that induces tissue-specific localization and functional polarization of peritoneal macrophages through the reversible induction of transcription factor GATA6. We further found that GATA6 in macrophages regulates gut IgA production through peritoneal B-1 cells. These results provide insight into the regulation of tissue-resident macrophage functional specialization by tissue-derived signals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.