ArticleNature chemical biology2014
Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions.
Article in Nature chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 108 citations in OpenAlex.
- Synthetic ion channel inhibitors enhance plant drought tolerance.Nature communications · 2026Article
- From Regulation to Application: The Role of Abscisic Acid in Seed and Fruit Development and Agronomic Production Strategies.International journal of molecular sciences · 2024Review
- Stabilization of dimeric PYR/PYL/RCAR family members relieves abscisic acid-induced inhibition of seed germination.Nature communications · 2024Article
- The Discovery of Highly Efficient and Promising ABA Receptor Antagonists for Agricultural Applications Based on APAn Modification.Molecules (Basel, Switzerland) · 2024Article
- Structure-guided engineering of a receptor-agonist pair for inducible activation of the ABA adaptive response to drought.Science advances · 2023Article
- An Anecdote on Prospective Protein Targets for Developing Novel Plant Growth Regulators.Molecular biotechnology · 2022Review
- Article
- Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- An Update on Crop ABA Receptors.Plants (Basel, Switzerland) · 2021Review
- Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Recent Advances in Plant Chemical Biology of Jasmonates.International journal of molecular sciences · 2020Review
- Selection and functional identification of a synthetic partial ABA agonist, S7.Scientific reports · 2020Article
- Overexpression of AtNCED3 gene improved drought tolerance in soybean in greenhouse and field conditions.Genetics and molecular biology · 2020Article
- Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast.The EMBO journal · 2019Article
- Abscisic Acid Receptors and Coreceptors Modulate Plant Water Use Efficiency and Water Productivity.Plant physiology · 2019Article
- A Chemical Biology View of Bioactive Small Molecules and a Binder-Based Approach to Connect Biology to Precision Medicines.Israel journal of chemistry · 2019Article
- Proteomic and Phosphoproteomic Analysis in Tobacco Mosaic Virus-Infected Tobacco (Nicotiana tabacum).Biomolecules · 2019Article
- A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors.Plant physiology · 2017Article
- Article
- Abscisic Acid as Pathogen Effector and Immune Regulator.Frontiers in plant science · 2017Review
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Authors and funding
15 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant stress hormone abscisic acid (ABA) is critical for several abiotic stress responses. ABA signaling is normally repressed by group-A protein phosphatases 2C (PP2Cs), but stress-induced ABA binds Arabidopsis PYR/PYL/RCAR (PYL) receptors, which then bind and inhibit PP2Cs. X-ray structures of several receptor-ABA complexes revealed a tunnel above ABA's 3' ring CH that opens at the PP2C binding interface. Here, ABA analogs with sufficiently long 3' alkyl chains were predicted to traverse this tunnel and block PYL-PP2C interactions. To test this, a series of 3'-alkylsulfanyl ABAs were synthesized with different alkyl chain lengths. Physiological, biochemical and structural analyses revealed that a six-carbon alkyl substitution produced a potent ABA antagonist that was sufficiently active to block multiple stress-induced ABA responses in vivo. This study provides a new approach for the design of ABA analogs, and the results validated structure-based design for this target class.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.