Evidence map›Paper›PMID 24792912›Full record

ArticleImmunity2014

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

Dror S Shouval, Amlan Biswas, Jeremy A Goettel, Katelyn McCann, Evan Conaway, Naresh S Redhu, Ivan D Mascanfroni, Ziad Al Adham, Sydney Lavoie, Mouna Ibourk and 19 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 349 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
349citing papers in PubMed, 1 pooled it
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

349 citing papers in PubMed, 1 synthesis or guideline pooled it, 566 citations in OpenAlex.

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  11. Immune development in early life.Nature immunology · 2026
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289 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 14 institutions in 7 countries.

Dror S ShouvalDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Amlan BiswasDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Jeremy A GoettelDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Katelyn McCannDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Evan ConawayDepartment of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Naresh S RedhuDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Ivan D MascanfroniCenter of Neurological Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Ziad Al AdhamDivision of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
Sydney LavoieDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Mouna IbourkDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Deanna D NguyenGastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Janneke N SamsomLaboratory of Pediatric Gastroenterology, Erasmus Medical Center-Sophia Children's Hospital, 3000 CA Rotterdam, the Netherlands; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Johanna C EscherDepartment of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, 3000 CA Rotterdam, the Netherlands; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Raz SomechPediatric Immunology Service, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52661, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Batia WeissDivision of Pediatric Gastroenterology and Nutrition, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer 52661, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Rita BeierDepartment of Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Laurie S ConklinDepartment of Gastroenterology, Children's National Medical Center, Washington, D.C. 20010, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Christen L EbensDivision of Pediatric Hematology and Oncology, University of Michigan, Ann Arbor, MI 48109, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Fernanda G M S SantosHospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 30130-100, Brazil; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Alexandre R FerreiraHospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 30130-100, Brazil; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Mary SherlockDivision of Gastroenterology, McMaster Children's Hospital, West Hamilton, Ontario L8N 3Z5, Canada; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Atul K BhanDepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Werner MüllerFaculty of Life Sciences, University of Manchester, Manchester M13 9PL, UK.
J Rodrigo MoraGastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Francisco J QuintanaCenter of Neurological Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Christoph KleinDr von Hauner Children's Hospital, Ludwig-Maximilians-University, 80337 Munich, Germany; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Aleixo M MuiseDivision of Gastroenterology, Hepatology, and Nutrition, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Bruce H HorwitzDepartment of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS).
Scott B SnapperDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA 02115, USA; interNational Early Onset Paediatric IBD Cohort Study (NEOPICS). Electronic address: ssnapper@hms.harvard.edu.
Harvard University · USBoston Children's Hospital · USBrigham and Women's Hospital · USCohort (United Kingdom) · GBHospital das Clínicas da Universidade Federal de Minas Gerais · BRHospital for Sick Children · CAEdmond and Lily Safra Children's Hospital · ILErasmus MC - Sophia Children’s Hospital · NLLudwig-Maximilians-Universität München · DEMassachusetts General Hospital · USMcMaster Children's Hospital · CAMedizinische Hochschule Hannover · DESheba Medical Center · ILUniversity of Manchester · GB

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
WIP in TCR signaling and actin reorganizationP01HL059561 · NHLBI · IMMUNE DISEASE INSTITUTE, INC. · PI GEHA, RAIF SALIM · 1997 to 2012
$21.8M
The Pathogenesis Of Colitis In A Novel Th2 Model Of IBDR01AI050950 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SNAPPER, SCOTT B · 2002 to 2013
$2.6M
Enhancing neonatal immunity to Streptococcus pneumoniaeR01AI100114 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MALLEY, RICHARD · 2012 to 2016
$2.1M
Role of aryl hydrocarbon receptor in IL-10 producing Tr1 regulatory cellsR56AI093903 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J. · 2016 to 2016
$413k
Exploring Regulatory T Cell Dysfunction in a Murine Model of ColitisR56AI050950 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SNAPPER, SCOTT B · 2008 to 2008
$336k
NHLBI NIH HHS HL59561NHLBI NIH HHS P01 HL059561NIAID NIH HHS AI50950NIAID NIH HHS R01 AI050950NIAID NIH HHS R01 AI100114NIAID NIH HHS R56 AI050950NIAID NIH HHS R56 AI093903NIDDK NIH HHS DK034854NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg) cells are each independently required to maintain immune tolerance. Here we show that IL-10 sensing by innate immune cells, independent of its effects on T cells, was critical for regulating mucosal homeostasis. Following wild-type (WT) CD4(+) T cell transfer, Rag2(-/-)Il10rb(-/-) mice developed severe colitis in association with profound defects in generation and function of Treg cells. Moreover, loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone-marrow-derived macrophages and their ability to secrete IL-10. Importantly, transfer of WT but not Il10rb(-/-) anti-inflammatory macrophages ameliorated colitis induction by WT CD4(+) T cells in Rag2(-/-)Il10rb(-/-) mice. Similar alterations in the generation and function of anti-inflammatory macrophages were observed in IL-10R-deficient patients with very early onset inflammatory bowel disease. Collectively, our studies define innate immune IL-10R signaling as a key factor regulating mucosal immune homeostasis in mice and humans.

Indexed as

Adoptive TransferAnimalsCell DifferentiationCell ProliferationCells, CulturedColitis, UlcerativeDNA-Binding ProteinsHumansImmune ToleranceImmunity, InnateInflammationInterleukin-10MacrophagesMiceMice, Inbred C57BLMice, KnockoutDNA-Binding ProteinsIL10 protein, mouseInterleukin-10Rag2 protein, mouseReceptors, Interleukin-10

Identifiers

PMID24792912
PMCPMC4513358
OpenAlexW2043897018

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.