Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors.

Victor M Pulgar, Jill Keith Harp

Open access · greenAbstract read

In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 33% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Victor M PulgarBiomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC, United States; Department of Life Sciences, Winston-Salem State University, Winston Salem, NC, United States; Department of Obstetrics & Gynecology, Wake Forest University School of Medicine, Winston Salem, NC, United States; Hypertension Research & Vascular Center, Wake Forest University School of Medicine, Winston Salem, NC, United States. Electronic address: vpulgar@wakehealth.edu.

Jill Keith HarpBiomedical Research Infrastructure Center, Winston-Salem State University, Winston Salem, NC, United States; Department of Life Sciences, Winston-Salem State University, Winston Salem, NC, United States; Physiology & Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, United States.

Wake Forest University · USWinston-Salem State University · US

Funding

Piperdyl analogs as cocaine pharmacotherapyP20MD000232 · NIMHD · WINSTON-SALEM STATE UNIVERSITY · PI HOWARD-VITAL, MICHELLE R · 2002 to 2006

$4.6M

NIMHD NIH HHS MD00232NIMHD NIH HHS P20 MD000232

6 · The paper itself

Abstract

Vascular effects of 4-aryl methoxypiperidinol compounds previously shown to share with cocaine the ability to inhibit the dopamine transporter are described. All the compounds tested inhibit KCl-induced and noradrenaline-dependent contractions in mesenteric arteries ex vivo. Thus, diphenylpyraline and its analogs may have a role as therapeutic options for the treatment of some of the cardiotoxic effects of cocaine intoxications.

Indexed as

AnimalsBenzhydryl CompoundsDopamine Uptake InhibitorsDose-Response Relationship, DrugMesenteric ArteriesMolecular StructureMuscle, Smooth, VascularNorepinephrinePiperidinesPotassium ChlorideRatsStructure-Activity RelationshipBenzhydryl CompoundsDopamine Uptake InhibitorsNorepinephrinePiperidinesPotassium ChlorideArterial contractionDopamine transporterPiperidinol-4

Identifiers

PMID24792462

DOI10.1016/j.bmcl.2014.04.040

PMCPMC4056188

OpenAlexW2059133463

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.