Evidence map›Paper›PMID 24792345›Full record

ReviewCurrent opinion in neurology2014

Autoimmune encephalitis as differential diagnosis of infectious encephalitis.

Thaís Armangue, Frank Leypoldt, Josep Dalmau

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
  2. BrainEuropean journal of nuclear medicine and molecular imaging · 2021
    Pooled it
  3. Journal of neurology · 2024
    Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Psychiatric manifestations of encephalitis.Annals of clinical and translational neurology · 2025
    Article
  11. Review
  12. A pediatric case of anti-GABAFrontiers in pediatrics · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Controversies in immunotherapy for anti-NMDA receptor encephalitis: a scoping review with a proposal of operational definitions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Thaís ArmangueaAugust Pi i Sunyer Biomedical Research Institute (IDIBAPS), Service of Neurology, Hospital Clinic, University of Barcelona bCatalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain cDepartment of Neurology, University of Pennsylvania, Philadelphia, USA.
Frank Leypoldt
Josep Dalmau
Biomedical Research Institute · USInstitució Catalana de Recerca i Estudis Avançats · ES

Funding

Paraneoplastic Disorders of the CNS: Autoantigen ProfilingR01NS077851 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DALMAU, JOSEP O. · 2011 to 2015
$1.9M
Autoimmunity Against Novel Antigens in Neuropsychiatric DysfunctionR01MH094741 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BALICE-GORDON, RITA J., DALMAU, JOSEP O. · 2011 to 2014
$1.3M
NIMH NIH HHS MH094741NIMH NIH HHS R01 MH094741NINDS NIH HHS R01 NS077851NINDS NIH HHS R01NS077851
6 · The paper itself

Abstract

purpose of reviewThis review describes the main types of autoimmune encephalitis with special emphasis on those associated with antibodies against neuronal cell surface or synaptic proteins, and the differential diagnosis with infectious encephalitis. RECENT

findingsThere is a continuous expansion of the number of cell surface or synaptic proteins that are targets of autoimmunity. The most recently identified include the metabotropic glutamate receptor 5 (mGluR5), dipeptidyl-peptidase-like protein-6 (DPPX), and γ-aminobutyric acid-A receptor (GABAAR). In these and previously known types of autoimmune encephalitis [N-methyl-D-aspartate receptor (NMDAR), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), γ-aminobutyric acid-B receptor (GABABR), leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein-like 2 (CASPR2)], the prodromal symptoms or types of presentations often suggest a viral encephalitis. We review here clues that help in the differential diagnosis with infectious encephalitis. Moreover, recent investigations indicate that viral encephalitis (e.g., herpes simplex) can trigger synaptic autoimmunity. In all these disorders, immunotherapy is usually effective. SUMMARY: Autoimmune encephalitis comprises an expanding group of potentially treatable disorders that should be included in the differential diagnosis of any type of encephalitis. VIDEO ABSTRACT: http://links.lww.com/CONR/A25,

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesBrainBrain DiseasesDiagnosis, DifferentialDipeptidyl-Peptidases and Tripeptidyl-PeptidasesEncephalitisEncephalitis, Herpes SimplexHashimoto DiseaseHumansIntracellular Signaling Peptides and ProteinsMagnetic Resonance ImagingMembrane ProteinsNerve Tissue ProteinsPotassium ChannelsProteinsalpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, humanAutoantibodiesCNTNAP2 protein, humanDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDPP6 protein, humanGRM5 protein, humanIntracellular Signaling Peptides and ProteinsLGI1 protein, humanMembrane ProteinsNerve Tissue ProteinsPotassium ChannelsProteinsReceptor, Metabotropic Glutamate 5Receptors, GABA-AReceptors, Glutamate

Identifiers

PMID24792345
PMCPMC4132825
OpenAlexW2029336271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.