ArticleNucleic acids research2014
Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 52 citations in OpenAlex.
- Prevalence and diversity of TAL effector-like proteins in fungal endosymbioticMicrobial genomics · 2024Article
- Transcription activator-like effector protects bacterial endosymbionts from entrapment within fungal hyphae.Current biology : CB · 2023Article
- TALE-induced cell death executors: an origin outside immunity?Trends in plant science · 2022Review
- TALEs as double-edged swords in plant-pathogen interactions: Progress, challenges, and perspectives.Plant communications · 2022Review
- Engineering protein and DNA tools for creating DNA-dependent protein switches.Methods in enzymology · 2022Article
- The genetic arms race between plant and Xanthomonas: lessons learned from TALE biology.Science China. Life sciences · 2021Review
- Molecular Dialogues between Early Divergent Fungi and Bacteria in an Antagonism versus a Mutualism.mBio · 2020Article
- A TAL effector-like protein of an endofungal bacterium increases the stress tolerance and alters the transcriptome of the host.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Chimerization Enables Gene Synthesis and Lentiviral Delivery of Customizable TALE-Based Effectors.International journal of molecular sciences · 2020Article
- Xanthomonas oryzae pv. oryzae TALE proteins recruit OsTFIIAγ1 to compensate for the absence of OsTFIIAγ5 in bacterial blight in rice.Molecular plant pathology · 2018Article
- Xanthomonas adaptation to common bean is associated with horizontal transfers of genes encoding TAL effectors.BMC genomics · 2017Article
- Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.Journal of experimental & clinical cancer research : CR · 2017Article
- Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening.Scientific reports · 2017Article
- A TALE-inspired computational screen for proteins that contain approximate tandem repeats.PloS one · 2017Article
- Computational and Pharmacological Evaluation of Ferrocene-Based Acyl Ureas and Homoleptic Cadmium Carboxylate Derivatives for Anti-diabetic Potential.Frontiers in pharmacology · 2017Article
- Exploiting the sequence diversity of TALE-like repeats to vary the strength of dTALE-promoter interactions.Synthetic biology (Oxford, England) · 2017Article
- Behind the lines-actions of bacterial type III effector proteins in plant cells.FEMS microbiology reviews · 2016Review
- A host basal transcription factor is a key component for infection of rice by TALE-carrying bacteria.eLife · 2016Article
- (±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum.Scientific reports · 2016Article
- A simple test for the cleavage activity of customized endonucleases in plants.Plant methods · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tandem repeats of transcription activator like effectors (TALEs) mediate sequence-specific DNA binding using a simple code. Naturally, TALEs are injected by Xanthomonas bacteria into plant cells to manipulate the host transcriptome. In the laboratory TALE DNA binding domains are reprogrammed and used to target a fused functional domain to a genomic locus of choice. Research into the natural diversity of TALE-like proteins may provide resources for the further improvement of current TALE technology. Here we describe TALE-like proteins from the endosymbiotic bacterium Burkholderia rhizoxinica, termed Bat proteins. Bat repeat domains mediate sequence-specific DNA binding with the same code as TALEs, despite less than 40% sequence identity. We show that Bat proteins can be adapted for use as transcription factors and nucleases and that sequence preferences can be reprogrammed. Unlike TALEs, the core repeats of each Bat protein are highly polymorphic. This feature allowed us to explore alternative strategies for the design of custom Bat repeat arrays, providing novel insights into the functional relevance of non-RVD residues. The Bat proteins offer fertile grounds for research into the creation of improved programmable DNA-binding proteins and comparative insights into TALE-like evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.