ReviewInternational immunology2014
Regulation of the gut microbiota by the mucosal immune system in mice.
Review in International immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Cecum microbiota composition, fermentation characteristics, and immunometabolic biomarkers of Yunshang black goat fed varying dietary energy and protein levels.Frontiers in microbiology · 2025Article
- Proteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function inAnimals : an open access journal from MDPI · 2024Article
- Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities.Biology of sex differences · 2023Article
- Relationship between the gut microbiota and bile acid composition in the ileal mucosa of Crohn's disease.Intestinal research · 2022Article
- Characterization of the bacterial microbiota across the different intestinal segments of the Qinghai semi-fine wool sheep on the Qinghai-Tibetan Plateau.Animal bioscience · 2021Article
- Evolution of animal immunity in the light of beneficial symbioses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- IMPARO: inferring microbial interactions through parameter optimisation.BMC molecular and cell biology · 2020Article
- Keep calm: the intestinal barrier at the interface of peace and war.Cell death & disease · 2019Review
- The Pacific harbor seal gut microbiota in Mexico: Its relationship with diet and functional inferences.PloS one · 2019Article
- Characteristics of Gut Microbiota in Patients With Rheumatoid Arthritis in Shanghai, China.Frontiers in cellular and infection microbiology · 2019Article
- First Insights into the Gut Microbiota of Mexican Patients with Celiac Disease and Non-Celiac Gluten Sensitivity.Nutrients · 2018Article
- A systematic approach to cancer: evolution beyond selection.Clinical and translational medicine · 2017Article
- Dendritic cell expression of the signaling molecule TRAF6 is required for immune tolerance in the lung.International immunology · 2017Article
- Interaction between the gut microbiome and mucosal immune system.Military Medical Research · 2017Review
- Experimental Evolution as an Underutilized Tool for Studying Beneficial Animal-Microbe Interactions.Frontiers in microbiology · 2016Review
- Monitoring Perinatal Gut Microbiota in Mouse Models by Mass Spectrometry Approaches: Parental Genetic Background and Breastfeeding Effects.Frontiers in microbiology · 2016Article
- Microbial activities and intestinal homeostasis: A delicate balance between health and disease.Cellular and molecular gastroenterology and hepatology · 2015Article
- Alternatives to antibiotics in animal agriculture: an ecoimmunological view.Pathogens (Basel, Switzerland) · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The benefits of commensal bacteria to the health of the host have been well documented, such as providing stimulation to potentiate host immune responses, generation of useful metabolites, and direct competition with pathogens. However, the ability of the host immune system to control the microbiota remains less well understood. Recent microbiota analyses in mouse models have revealed detailed structures and diversities of microbiota at different sites of the digestive tract in mouse populations. The contradictory findings of previous studies on the role of host immune responses in overall microbiota composition are likely attributable to the high β-diversity in mouse populations as well as technical limitations of the methods to analyze microbiota. The host employs multiple systems to strictly regulate their interactions with the microbiota. A spatial segregation between the host and microbiota is achieved with the mucosal epithelium, which is further fortified with a mucus layer on the luminal side and Paneth cells that produce antimicrobial peptides. When commensal bacteria or pathogens breach the epithelial barrier and translocate to peripheral tissues, the host immune system is activated to eliminate them. Defective segregation and tissue elimination of commensals result in exaggerated inflammatory responses and possibly death of the host. In this review, we discuss the current understanding of mouse microbiota, its common features with human microbiota, the technologies utilized to analyze microbiota, and finally the challenges faced to delineate the role of host immune responses in the composition of the luminal microbiota.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.