ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Association of autophagy-related 16-like 1 (ATG16L1) gene polymorphism with sepsis severity in patients with sepsis and ventilator-associated pneumonia.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Association between the Lymphotoxin-BioMed research international · 2020Pooled it
- Myeloid autophagy genes protect mice against fatal TNF- and LPS-induced cytokine storm syndromes.Autophagy · 2023Article
- ADAM10-a "multitasker" in sepsis: focus on its posttranslational target.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Association of HLA-DPA1 polymorphism with prolonged mechanical ventilation in patients undergoing liver transplantation.Korean journal of anesthesiology · 2022Article
- Effect of rs4719839 polymorphism on risk of ventilator-associated pneumonia, expression of microRNA-148 and autophagy-related 16-like 1 (ATG16L1).Journal of cellular and molecular medicine · 2020Article
- Observational
- Hidradenitis suppurativa: infection, autoimmunity, or both?Therapeutic advances in musculoskeletal disease · 2019Review
- Risk Factors of Ventilator-Associated Pneumonia in Critically III Patients.Frontiers in pharmacology · 2019Article
- Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit.Experimental and therapeutic medicine · 2018Article
- Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis.Innate immunity · 2018Article
- Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis model.Scientific reports · 2018Article
- Association between genetic polymorphisms in the autophagy-related 5 gene promoter and the risk of sepsis.Scientific reports · 2017Article
- Vitamin D differentially regulatesWorld journal of gastroenterology · 2016Article
- Autophagy in Pulmonary Diseases.American journal of respiratory and critical care medicine · 2016Review
- Genipin alleviates sepsis-induced liver injury by restoring autophagy.British journal of pharmacology · 2016Article
- Review
- Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is a highly conserved mechanism of eukaryotic cells implicated in cell homeostasis and elimination of intracellular pathogens. Functional polymorphisms in genes encoding for autophagy have been associated with susceptibility to inflammatory and infectious diseases, but data on severe infections are missing. The aim of the present study was to assess whether polymorphisms in genes encoding proteins involved in autophagy influence susceptibility to ventilator-associated pneumonia (VAP). Mechanically ventilated patients with VAP were studied. Genotyping for autophagy-related 16-like 1 (ATG16L1, rs2241880) functional polymorphism was performed using the TaqMan single-nucleotide assay. Monocytes were isolated from patients and stimulated with lipopolysaccharide (LPS). Tumor necrosis factor-α (TNF-α) was measured in the supernatants of monocytes using an enzyme-linked immunosorbent assay. Procalcitonin (PCT) was also measured in the serum of patients by an immuno-time-resolved amplified cryptate technology assay. A total of 155 patients with VAP were enrolled in the study. Carriage of the minor A allele of ATG16L1 was associated with septic shock with at least one organ failure (odds ratio (OR): 2.40, p: 0.036). TNF-α production was significantly greater among the carriers of the polymorphism presenting with at least one organ failure (p: 0.040). PCT was increased upon worsening to septic shock and organ failure only among carriers of the minor frequency A alleles. In a homogeneous cohort of septic patients with VAP, the carriage of autophagy polymorphisms predisposes to VAP severity and septic shock development. This may be related with predisposition to immunoparalysis.
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