ReviewCurrent opinion in genetics & development2014
Morphomechanics: transforming tubes into organs.
Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- A method for investigating spatiotemporal growth patterns at cell and tissue levels during C-looping in the embryonic chick heart.iScience · 2022Article
- Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea.Royal Society open science · 2021Article
- Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells.Developmental cell · 2020Article
- On the Cardiac Loop and Its Failing: Left Ventricular Outflow Tract Obstruction.Journal of the American Heart Association · 2020Review
- The Chiral Looping of the Embryonic Heart Is Formed by the Combination of Three Axial Asymmetries.Biophysical journal · 2020Article
- The Memory of the Heart.Journal of cardiovascular development and disease · 2018Review
- Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis.Journal of visualized experiments : JoVE · 2018Article
- Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.Nature communications · 2018Article
- Modeling branching morphogenesis using materials with programmable mechanical instabilities.Current opinion in biomedical engineering · 2018Article
- Human Brain Organoids on a Chip Reveal the Physics of Folding.Nature physics · 2018Article
- The Role of Cerl2 in the Establishment of Left-Right Asymmetries during Axis Formation and Heart Development.Journal of cardiovascular development and disease · 2017Review
- Claudins in morphogenesis: Forming an epithelial tube.Tissue barriers · 2017Review
- A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contraction.Development (Cambridge, England) · 2017Article
- Computational models of airway branching morphogenesis.Seminars in cell & developmental biology · 2017Review
- Tissue growth constrained by extracellular matrix drives invagination during optic cup morphogenesis.Biomechanics and modeling in mechanobiology · 2016Article
- Fluid mechanics as a driver of tissue-scale mechanical signaling in organogenesis.Current pathobiology reports · 2016Article
- Interplay between cardiac function and heart development.Biochimica et biophysica acta · 2016Review
- On Buckling Morphogenesis.Journal of biomechanical engineering · 2016Article
- From genes to folds: a review of cortical gyrification theory.Brain structure & function · 2015Review
- Mechanically patterning the embryonic airway epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
After decades focusing on the molecular and genetic aspects of organogenesis, researchers are showing renewed interest in the physical mechanisms that create organs. This review deals with the mechanical processes involved in constructing the heart and brain, concentrating primarily on cardiac looping, shaping of the primitive brain tube, and folding of the cerebral cortex. Recent studies suggest that differential growth drives large-scale shape changes in all three problems, causing the heart and brain tubes to bend and the cerebral cortex to buckle. Relatively local changes in form involve other mechanisms such as differential contraction. Understanding the mechanics of organogenesis is central to determining the link between genetics and the biophysical creation of form and structure.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.