ReviewCurrent opinion in genetics & development2014
MicroRNAs and their roles in developmental canalization.
Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 85 citations in OpenAlex.
- The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026Review
- Beyond the heat shock pathway: Heat stress responses in Drosophila development.Developmental biology · 2025Review
- MIR164B ensures robust Arabidopsis leaf development by compensating for compromised POLYCOMB REPRESSIVE COMPLEX2 function.The Plant cell · 2024Article
- Identification of novel microRNAs in the embryonic mouse brain using deep sequencing.Molecular and cellular biochemistry · 2024Article
- High CO2 adaptation mechanisms revealed in the miR156-regulated flowering time pathway.PLoS computational biology · 2023Article
- Vegetative phase change causes age-dependent changes in phenotypic plasticity.The New phytologist · 2023Article
- Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes.Biology of sex differences · 2023Article
- Direct observation of the evolution of cell-type-specific microRNA expression signatures supports the hematopoietic origin model of endothelial cells.Evolution & development · 2023Article
- Canalization of Phenotypes-When the Transcriptome is Constantly but Weakly Perturbed.Molecular biology and evolution · 2023Article
- Reversing the miRNA -5p/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs.RNA (New York, N.Y.) · 2022Article
- Evolution after Whole-Genome Duplication: Teleost MicroRNAs.Molecular biology and evolution · 2021Article
- Adaptive and nonadaptive plasticity in changing environments: Implications for sexual species with different life history strategies.Ecology and evolution · 2021Article
- microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.Nucleic acids research · 2021Article
- Gene regulatory network stabilized by pervasive weak repressions: microRNA functions revealed by the May-Wigner theory.National science review · 2019Article
- Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress.iScience · 2019Article
- microRNA-14 as an efficient suppressor to switch off ecdysone production after ecdysis in insects.RNA biology · 2019Article
- Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression.Genes · 2019Review
- Mechanistic Insights into MicroRNA-Mediated Gene Silencing.Cold Spring Harbor perspectives in biology · 2019Review
- MicroRNAs in Drosophila Cancer Models.Advances in experimental medicine and biology · 2019Review
- Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Robustness is a fundamental property of biological systems. The type of robustness that ensures uniform phenotypic outcomes in the face of variation during an organism's development is called canalization. Here, we discuss the roles that microRNAs play in providing canalization to animal development, citing recent theoretical and experimental advances. MicroRNAs repress protein expression, and they do this in ways that create thresholds in expression and provide adaptation to regulatory networks. Numerous examples have now been described where the developmental impact of environmental variation is suppressed by individual microRNAs. A recent paper has found that the impact of genomic variation between individuals is similarly suppressed by a microRNA operating in a developmental network. Thus, genetic variability is held in check, which is potentially important for both animal evolution and manifestation of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.