Evidence map›Paper›PMID 24791650›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014

Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.

Brinda K Rana, Burcu F Darst, Cinnamon Bloss, Pei-An Betty Shih, Colin Depp, Caroline M Nievergelt, Matthew Allison, J Kellogg Parsons, Nicholas Schork, Dilip V Jeste

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Genetic Contributions of Inflammation to Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Pooled it
  3. Resilience in Older People: A Concept Analysis.Healthcare (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Article
  6. Genotype, resilience and function and physical activity post hip fracture.International journal of orthopaedic and trauma nursing · 2019
    Article
  7. Strategies for successful aging: a research update.Current psychiatry reports · 2014
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Brinda K RanaSam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA.
Burcu F DarstScripps Translational Science Institute, Scripps Genomic Medicine, Scripps Health, La Jolla, CA.
Cinnamon BlossScripps Translational Science Institute, Scripps Genomic Medicine, Scripps Health, La Jolla, CA.
Pei-An Betty ShihSam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA.
Colin DeppSam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA; Veterans Affairs San Diego Healthcare System, San Diego, CA.
Caroline M NievergeltSam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA.
Matthew AllisonDepartment of Family and Preventive Medicine, University of California, San Diego, CA.
J Kellogg ParsonsDepartment of Surgery, Division of Urologic Oncology, University of California, San Diego, CA.
Nicholas SchorkJ. Craig Venter Institute, La Jolla, CA.
Dilip V JesteSam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA. Electronic address: djeste@ucsd.edu.
University of California, San Diego · USInstitute on Aging · USScripps Health · USJ. Craig Venter Institute · USVA San Diego Healthcare System · US

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
Research Methods CoreP30MH080002 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JESTE, DILIP V. · 2007 to 2011
$9.6M
FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
CORE--RESEARCH NETWORK DEVELOPMENT COREP30MH066248 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JESTE, DILIP V. · 2002 to 2006
$7.4M
Solving EPHX2 and PUFA Interactions in Anorexia NervosaR01MH106781 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2016 to 2020
$2.0M
Genetic and Epigenetic Factors of Age-Related Cognitive Decline - A Twin StudyK01AG035031 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, BRINDA K · 2010 to 2014
$614k
Genetic Study of PP-Fold Polypeptide-Receptor Axis on Metabolic Syndrome RiskK01DK087813 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2011 to 2014
$544k
NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NIA NIH HHS 1K01AG035031NIA NIH HHS K01 AG035031NIDDK NIH HHS K01 DK087813NIDDK NIH HHS K01DK087813NIMH NIH HHS P30 MH066248NIMH NIH HHS P30MH066248NIMH NIH HHS P30 MH080002NIMH NIH HHS R01 MH106781NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

objectiveOptimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults.

designCandidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT).

participants426 women from WHI older than age 50 years, and 509 men older than age 55 years (age 50 years for African American men) from SELECT. MEASUREMENTS: 65 candidate gene SNPs that were judged by consensus, based on a literature review, as being related to predisposition to optimism and resilience, and 31 ancestry informative marker SNPs, genotyped from blood-based DNA samples and self-report scales for trait optimism, resilience, and depressive symptoms.

resultsUsing a Bonferroni threshold for significant association (p = 0.00089), there were no significant associations for individual SNPs with optimism or resilience in single-locus analyses. Exploratory multi-locus polygenic analyses with p <0.05 showed an association of optimism with SNPs in MAOA, IL10, and FGG genes, and an association of resilience with a SNP in MAOA gene.

conclusionsCorrecting for Type I errors, there were no significant associations of optimism and resilience with specific gene SNPs in single-locus analyses. Positive psychological traits are likely to be genetically complex, with many loci having small effects contributing to phenotypic variation. Our exploratory multi-locus polygenic analyses suggest that larger sample sizes and complementary approaches involving methods such as sequence-based association studies, copy number variation analyses, and pathway-based analyses could be useful for better understanding the genetic basis of these positive psychological traits.

Indexed as

Resilience, PsychologicalAgedAged, 80 and overAgingDepressionFemaleFibrinogens, AbnormalGenetic Association StudiesGenotypeHumansInterleukin-10MaleMiddle AgedMonoamine OxidaseMultifactorial InheritancePersonalityfibrinogen gamma'Fibrinogens, AbnormalIL10 protein, humanInterleukin-10Monoamine Oxidasemonoamine oxidase A, humanagingdepressiongenotypingOptimismresiliencesingle-nucleotide polymorphisms

Identifiers

PMID24791650
PMCPMC4163500
OpenAlexW2080353250

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.