Evidence map›Paper›PMID 24791067›Full record

ArticleJournal of toxicologic pathology2014

Establishment of a model of spontaneously-running-Tokushima-shikoku rats with left atrial thrombosis.

Takamasa Ohnishi, Fumiko Hisaoka, Masaki Morishima, Akira Takahashi, Nagakatsu Harada, Kazuaki Mawatari, Hidekazu Arai, Emiko Yoshioka, Satomi Toda, Izumi Keisuke and 1 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicologic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Animal model of left atrial thrombus in congestive heart failure in rats.American journal of physiology. Heart and circulatory physiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Takamasa OhnishiDepartment of Nutrition Management, Faculty of Health Science, Hyogo University, 2301 Shinzaike, Hiraoka-cho, Kakogawa, Hyogo 675-0195, Japan ; Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Fumiko HisaokaFaculty of Human Life Science, Shikoku University, 23-1 Ebisuno Furukawa, Oujinn-cho, Tokushima, Tokushima 771-1192, Japan.
Masaki MorishimaDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Akira TakahashiDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Nagakatsu HaradaDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Kazuaki MawatariDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Hidekazu AraiDepartment of Laboratory of Clinical Nutrition Management, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, 422-8526 Shizuoka, Japan.
Emiko YoshiokaDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Satomi TodaDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Izumi KeisukeDepartment of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Yutaka NakayaDepartment of Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, Tokushima 770-8503, Japan.
Tokushima University · JPFood & Nutrition · NLHyogo University · JPShikoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies that investigate the underlying mechanisms of disease and treatment options typically require the use of a suitable animal model. Few suitable animal models exist for left atrial thrombosis. Here, we demonstrated that the Spontaneously-Running-Tokushima-Shikoku (SPORTS) rat - a Wistar strain known for its running ability-is predisposed to the development of thrombi in the left atrium. We investigated the incidence of left atrial thrombosis in male (n = 16) and female (n = 17) SPORTS rats and observed organized atrial thrombosis in 57% and 38% of males and female rats, respectively. In the male rats, systolic blood pressures and heart rates were significantly higher in SPORTS rats than in control Wistar rats. We could not find any evidence of arrhythmias, such as atrial fibrillation, during electrocardiographic examination of SPORTS rats. We believe that the SPORTS rat could serve as a new research model for left atrial thrombosis; further, it may be suitable for research investigating the development of new antithrombotic approaches for the control of atrial thrombosis or familial thrombophilia in humans.

Indexed as

atrial thrombosisheartrat

Identifiers

PMID24791067
PMCPMC4000073
OpenAlexW2022259957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.