ArticleBioMed research international2014
The effects of acute hydrogen sulfide poisoning on cytochrome P450 isoforms activity in rats.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Warfarin-Durian interaction: A case study bridging clinical outcomes and metabolic profiling through metabolomics.Toxicology reports · 2026Article
- Case report: Analysis of a case of hydrogen sulfide poisoning in a waste treatment plant.Frontiers in public health · 2023Article
- Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs.Frontiers in pharmacology · 2022Article
- The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats.BioMed research international · 2017Article
- Assessment of effect of Zhu-tan Tong-luo decoction on CYP450 isoforms activity of rats.International journal of clinical and experimental medicine · 2015Article
- Effect of acute paraquat poisoning on CYP450 isoforms activity in rats by cocktail method.International journal of clinical and experimental medicine · 2015Article
- Assessment of the effect of ketamine on cytochrome P450 isoforms activity in rats by cocktail method.International journal of clinical and experimental medicine · 2015Article
- Evaluation of the impact of Flos Daturae on rat hepatic cytochrome P450 enzymes by cocktail probe drugs.International journal of clinical and experimental medicine · 2015Article
- Effect of Radix Sophorae Flavescentis on activity of CYP450 isoforms in rats.International journal of clinical and experimental medicine · 2015Article
- Effect of ademetionine on cytochrome P450 isoforms activity in rats.International journal of clinical and experimental medicine · 2015Article
- Effect of Radix Sophorae Tonkinensis on the activity of cytochrome P450 isoforms in rats.International journal of clinical and experimental medicine · 2015Article
- The effect of MS-275 on CYP450 isoforms activity in rats by cocktail method.International journal of clinical and experimental pathology · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen sulfide (H2S) is the second leading cause of toxin related death (after carbon monoxide) in the workplace. H2S is absorbed by the upper respiratory tract mucosa, and it causes histotoxic hypoxemia and respiratory depression. Cocktail method was used to evaluate the influences of acute H2S poisoning on the activities of cytochrome P450 isoforms CYP2B6, CYP2D6, CYP3A4, CYP1A2, CYP2C19, and CYP2C9, which were reflected by the changes of pharmacokinetic parameters of six specific probe drugs, bupropion, metoprolol, midazolam, phenacetin, omeprazole, and tolbutamide, respectively. The experimental rats were randomly divided into two groups, control group and acute H2S poisoning group (inhaling 300 ppm for 2 h). The mixture of six probes was given to rats by oral administration and the blood samples were obtained at a series of time points through the caudal vein. The concentrations of probe drugs in rat plasma were measured by LC-MS. The results for acute H2S poisoning and control groups were as follows: there was a statistically significant difference in the AUC and C max for bupropion, metoprolol, phenacetin, and tolbutamide, while there was no statistical pharmacokinetic difference for midazolam and omeprazole. Acute H2S poisoning could inhibit the activity of CYP2B6, CYP2D6, CYP1A2, and CYP2C9 in rats.
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