Evidence map›Paper›PMID 24790873›Full record

ArticleInternational journal of ophthalmology2014

Retinopathy in non diabetics, diabetic retinopathy and oxidative stress: a new phenotype in Central Africa?

Benjamin Longo-Mbenza, Moise Mvitu Muaka, Wayiza Masamba, Lucien Muizila Kini, Igor Longo Phemba, Dalida Kibokela Ndembe, Doris Tulomba Mona

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
  8. Review
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  13. Review
  14. Vitamin DJournal of diabetes research · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Benjamin Longo-MbenzaWalter Sisulu University, Faculty of Health Sciences, Walter Sisulu University, Private Bag X1, Mthatha 5117, South Africa.
Moise Mvitu MuakaDepartment of Ophthalmology, University of Kinshasa, Kinshasa 11, DR Congo.
Wayiza MasambaDepartment of Chemistry and Chemical Technology, Walter Sisulu University, Private Bag X1, Mthatha 5117, South Africa.
Lucien Muizila KiniDepartment of Family Medicine, Umtata General Hospital, Walter Sisulu University, Private Bag X1, Mthatha 5117, South Africa.
Igor Longo PhembaSchool of International Studies, Wendzou Medical College, Wenzhou 325005, Zhejiang Province, China.
Dalida Kibokela NdembeDepartment of Neuropsychiatry, University of Kinshasa, Kinshasa 11, DR Congo.
Doris Tulomba MonaBiostatistics Unit, Lomo Medical Center and Heart of Africa Center of Cardiology, Kinshasa, Kinshasa 11, DR Congo.
University of Kinshasa · CDWalter Sisulu University · ZAAfrica Center · USMthatha General Hospital · ZAWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the rates of retinopathy without diabetes and diabetic retinopathy (DR), associated with some markers of oxidative stress, antioxidants and cardiometabolic risk factors.

methodsWe determined the prevalence of DR in 150 type 2 diabetes mellitus (T2DM) patients, that of retinopathy in 50 non diabetics, the levels of body mass index (BMI), waist circumference (WC), blood pressure, lipids, 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), gamma-glutamyl transferase GT (GGT), oxidized low-density lipoprotein (OxLDL), thiobarbituric acid reacting substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), uric acid, creatinine, albumin, total antioxidant status (TAOS), zinc, selenium, magnesium, vitamin C, vitamin D, vitamin E, glucose, apolipoprotein B (ApoB).

resultsThe prevalences of DR at 53y and Rtp at 62y were 44% (n=66) and 10% (n=5), respectively. The highest levels of 8-isoprostane, 8-OHdG, TBARS, SOD, and OxLDL were in DR. The lowest levels of vitamin D, vitamin C, TAOS, and vitamin E were in DR. In the case-control study discriminant analysis, the levels of vitamin C, vitamin D, ApoB, 8-OHdG, creatinine, Zn, vitamin E, and WC distinguished significantly non-diabetics without DR (controls), T2DM patients without DR and T2DM patients with DR.

conclusionAnticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2 diabetics. Prevention of oxidative stress and abdominal obesity is needed. Supplementation in vitamin C, D, and E should be recommended as complement therapies of T2DM.

Indexed as

Africaanticipationapolipoprotein Bdiabetic retinopathydiscriminant analysisoxidative stress

Identifiers

PMID24790873
PMCPMC4003085
OpenAlexW1589343975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.