Evidence map›Paper›PMID 24790730›Full record

ArticleJournal of cancer therapeutics & research2014

Apoptosis-Related Single Nucleotide Polymorphisms and the Risk of Non-Small Cell Lung Cancer in Women.

Anand Pathak, Angela S Wenzlaff, Paula L Hyland, Michele L Cote, Greg R Keele, Susan Land, Matthew L Boulton, Ann G Schwartz

Open access · hybridAbstract read
In one paragraph

Article in Journal of cancer therapeutics & research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  3. Article
  4. In silico approach to the analysis of SNPs in the human APAF1 gene.Turkish journal of biology = Turk biyoloji dergisi · 2019
    Article
  5. Observational
  6. CD40 -1C>T polymorphism and the risk of lung cancer in a Chinese population.International journal of clinical and experimental pathology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Anand PathakClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850.
Angela S WenzlaffPopulation Studies and Disparities Research Program, Karmanos Cancer Institute, Wayne State University, 4100 John R., Mail Code: MM04EP, Detroit, MI 48201.
Paula L HylandGenetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850.
Michele L CotePopulation Studies and Disparities Research Program, Karmanos Cancer Institute, Wayne State University, 4100 John R., Mail Code: MM04EP, Detroit, MI 48201.
Greg R KeelePopulation Studies and Disparities Research Program, Karmanos Cancer Institute, Wayne State University, 4100 John R., Mail Code: MM04EP, Detroit, MI 48201.
Susan LandApplied Genomics Technology Center and Department of Obstetrics & Gynecology, Wayne State University School of Medicine, CS Mott Center. 275 East Hancock St., Detroit MI 48201.
Matthew L BoultonPreventive Medicine Residency, Department of Epidemiology, University of Michigan School of Public Health, 1415 Washington Heights -M5216 SPH II Ann Arbor, MI 48109.
Ann G SchwartzPopulation Studies and Disparities Research Program, Karmanos Cancer Institute, Wayne State University, 4100 John R., Mail Code: MM04EP, Detroit, MI 48201.
Genomics (United Kingdom) · GB

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
Adenocarinoma of the Lung in WomenR01CA087895 · NCI · WAYNE STATE UNIVERSITY · PI SCHWARTZ, ANN G · 2001 to 2005
$3.0M
Intramural NIH HHS Z99 CA999999NCI NIH HHS N01 PC035145NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA087895
6 · The paper itself

Abstract

backgroundGermline apoptosis-related single nucleotide polymorphisms (SNPs) have been shown to contribute to the risk of developing non-small cell lung cancer (NSCLC). However, very few studies have looked specifically at apoptosis-related SNPs in a racially-stratified analysis of white and African-American women.

methodsWe examined the risk of developing NSCLC associated with 98 germline SNPs in 32 apoptosis-related genes among women in a population-based case-control study from the Detroit metropolitan area. We examined 453 cases of NSCLC and 478 control subjects. We used an unconditional logistic regression with a dominant model, stratified by race, and adjusted for age, pack-years smoked, ever/never smoking status, family history of lung cancer, history of COPD, BMI and education.

resultsOur logistic regression identified 3 significant apoptosis-related SNPs in whites (

conclusionIn whites, only SNPs

Indexed as

APAF-1apoptosisATMCD40femalesnon-small cell lung cancer (NSCLC)single nucleotide polymorphismsTNFTP63

Identifiers

PMID24790730
PMCPMC4002173
OpenAlexW2163102388

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.