ArticleInternational journal of endocrinology and metabolism2014
Gender differences in risk factors of congenital hypothyroidism: an interaction hypothesis examination.
Article in International journal of endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Effect of timely diagnosis and treatment on growth and body proportionality of children with congenital hypothyroidism.Frontiers in endocrinology · 2025Article
- The Impact of Seasonal Changes on Thyroxine and Thyroid-Stimulating Hormone in Newborns.International journal of neonatal screening · 2021Article
- Congenital Hypothyroidism and its Related Factors in an Iranian Population: A Retrospective Study in Semnan (2011-2016).International journal of preventive medicine · 2020Article
- Risk factors associated with congenital hypothyroidism: a case-control study in southeast Iran.Electronic physician · 2018Article
- Short-term rosuvastatin therapy prevents contrast-induced acute kidney injury in female patients with diabetes and chronic kidney disease: a subgroup analysis of the TRACK-D study.Journal of thoracic disease · 2016Article
- Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses.PloS one · 2016Article
- Baseline Religion Involvement Predicts Subsequent Salivary Cortisol Levels Among Male But not Female Black Youth.International journal of endocrinology and metabolism · 2015Article
- The Role of Neck Ultrasonography and Nuclear Imaging in the Diagnosis of Congenital Hypothyroidism.Indian journal of endocrinology and metabolismArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have demonstrated an increased risk of congenital hypothyroidism (CH) in girls in comparison to boys.
objectivesThe aim of this study was to determine the potential interactions that are able to change the effect of gender on congenital hypothyroidism. PATIENTS AND
methodsWe conducted a matched 1:4 case-control study in Hamadan Province, western of Iran, from 2005 to 2011. Based on screening program data, neonates with TSH ≥ 10 mU/L and T4 ≤ 6.4 μg/dL were considered as congenital hypothyroidism (Cases). Cases and controls were matched regarding the year and place of birth. Data was analyzed using two different approaches including propensity score and multiple conditional logistic regression model.
resultsA total of 277 cases and 1036 controls were included in the study. Girls accounted for 57.4% of the cases and 51.2% of controls (P = 0.065). Based on the multiple conditional logistic regressions, only the interaction of gender (girl) and birth season (summer) increased the likelihood of CH significantly (OR = 3.09; 95% CI: 1.09-8.74; P = 0.034). On the other hand, the ORs of the interaction of gender and all other factors (except for birth season) were not statistically significant in CH.
conclusionsBirth season might act as an interaction that is able to increase the risk of CH in girls. Accordingly, awareness of the birth season could help policymakers who plan preventive programs to reduce the false negative results among neonates, especially girls.
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