ArticleInternational journal of pediatrics2014
Free radicals and antioxidant status in protein energy malnutrition.
Article in International journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Increased risk of aminoglycoside-induced hearing loss in MDR-TB patients with HIV coinfection.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Pooled it
- Does Resveratrol Impact Oxidative Stress Markers in Patients with Head and Neck Cancer Receiving Home Enteral Nutrition?Nutrients · 2025Trial
- Copeptin and albumin in children with undernutrition.Frontiers in pediatrics · 2026Article
- Re-telling the story of aminoglycoside ototoxicity: tales from sub-Saharan Africa.Frontiers in neurology · 2024Article
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- Unhealthy Dieting During the COVID-19 Pandemic: An Opinion Regarding the Harmful Effects on Brain Health.Frontiers in nutrition · 2022Article
- Effectiveness of forest honey (F1000Research · 2022Article
- Malnutrition, poor post-natal growth, intestinal dysbiosis and the developing lung.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Association between the maternal protein nutrition status during pregnancy and the risk of preterm birth.Maternal & child nutrition · 2021Article
- Aminoglycoside-induced Hearing Loss Among Patients Being Treated for Drug-resistant Tuberculosis in South Africa: A Prediction Model.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Malnutrition impairs mitochondrial function and leukocyte activation.Nutrition journal · 2019Article
- Adverse outcome pathway for aminoglycoside ototoxicity in drug-resistant tuberculosis treatment.Archives of toxicology · 2019Article
- Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet.Toxicological research · 2018Article
- Analysis of oxidative stress-related markers in critically ill polytrauma patients: An observational prospective single-center study.Bosnian journal of basic medical sciences · 2018Observational
- Maternal Protein Malnutrition: Current and Future Perspectives of Spirulina Supplementation in Neuroprotection.Frontiers in neuroscience · 2018Review
- Oxidative stress biomarkers in pediatric sepsis: a prospective observational pilot study.Redox report : communications in free radical research · 2017Article
- Circulating Protein Carbonyls, Antioxidant Enzymes and Related Trace Minerals among Preterms with Respiratory Distress Syndrome.Journal of clinical and diagnostic research : JCDR · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Objectives. The aim of this study was to evaluate oxidant and antioxidant status in children with different grades of Protein Energy Malnutrition (PEM). Subjects/Methods. A total of two hundred fifty (250) children (age range: 6 months to 5 years) living in eastern UP, India, were recruited. One hundred and ninety-three (193) of these children had different grades of PEM (sixty-five (65) children belong to mild, sixty (60) to moderate, and sixty-eight (68) to severe group). Grading in group was done after standardization in weight and height measurements. Fifty-seven (57) children who are age and and sex matched, healthy, and well-nourished were recruited from the local community and used as controls after checking their protein status (clinical nutritional status) with height and weight standardization. Redox homeostasis was assessed using spectrophotometric/colorimetric methods. Results. In our study, erythrocyte glutathione (GSH), plasma Cu, Zn-superoxide dismutase (Cu,Zn-SOD,EC 1.15.1.1), ceruloplasmin (Cp), and ascorbic acid were significantly (P < 0.001) more decreased in children with malnutrition than controls. Plasma malondialdehyde (MDA), and protein carbonyl (PC) were significantly (P < 0.001) raised in cases as compared to controls. Conclusion. Stress is created as a result of PEM which is responsible for the overproduction of reactive oxygen species (ROSs). These ROSs will lead to membrane oxidation and thus an increase in lipid peroxidation byproducts such as MDA and protein oxidation byproducts such as PC mainly. Decrease in level of antioxidants suggests an increased defense against oxidant damage. Changes in oxidant and antioxidant levels may be responsible for grading in PEM.
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Registered trials
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