ArticleClinical and experimental gastroenterology2014
A systematic review of transarterial embolization versus emergency surgery in treatment of major nonvariceal upper gastrointestinal bleeding.
Article in Clinical and experimental gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04902248 (Endoscopic Application of Over-the-scope Clips), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endoscopic Application of Over-the-scope Clips (OTSC) vs. Angiographic Embolization in Patients With Refractory Non-variceal Upper Gastrointestinal Bleeding: a Multicenter Randomized Comparison
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- [Guidelines for Non-variceal Upper Gastrointestinal Bleeding].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2020Guideline
- Perforated and bleeding peptic ulcer: WSES guidelines.World journal of emergency surgery : WJES · 2020Guideline
- Medical versus surgical treatment for refractory or recurrent peptic ulcer.The Cochrane database of systematic reviews · 2016Pooled it
- Transcatheter arterial embolization versus surgery for refractory non-variceal upper gastrointestinal bleeding: a meta-analysis.World journal of emergency surgery : WJESPooled it
- Efficacy and safety of empiric transcatheter arterial embolization for acute arterial upper gastrointestinal bleeding: A tertiary-care, single-center experience.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Hemostatic powder TC-325 as first-line treatment option for malignant gastrointestinal bleeding: a cost-utility analysis in the United Kingdom.Endoscopy · 2025Article
- Comparison of the efficacy and safety of super-selective and selective transcatheter arterial embolization in non-variceal gastrointestinal bleeding.Frontiers in medicine · 2025Article
- Multidisciplinary Management of a Patient with acute Oesophageal Necrosis and Severe Neurological Symptoms with Full Recovery.European journal of case reports in internal medicine · 2025Article
- Comprehensive insights on treatment modalities with conventional and herbal drugs for the treatment of duodenal ulcers.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Point-of-care ultrasound in the diagnosis and treatment of Budd-Chiari syndrome: A rare case report and literature review.Heliyon · 2024Article
- Endoscopic Visualization of the Embolization Coil With Subsequent Endoscopic Therapy: A Case Report.Cureus · 2024Article
- Efficacy of transcatheter arterial embolization in treating nonvariceal gastric remnant bleeding: a retrospective 5-year study.BMC gastroenterology · 2024Article
- Article
- Review
- Recurrent Post-Traumatic Adrenal Bleeding after Transcatheter Arterial Embolization: A Case Report.Journal of the Korean Society of Radiology · 2023Article
- [59/m-Blood in vomit and tarry stools : Preparation for the medical specialist examination: part 30].Chirurgie (Heidelberg, Germany) · 2023Article
- Reduced mortality for over-the-scope clips (OTSC) versus surgery for refractory peptic ulcer bleeding: a retrospective study.Surgical endoscopy · 2023Article
- Transarterial embolization of acute non-neurologic bleeding using Ethylene Vynil Alcohol Copolymer: a single-Centre retrospective study.CVIR endovascular · 2023Article
- T cells, NK cells, and tumor-associated macrophages in cancer immunotherapy and the current state of the art of drug delivery systems.Frontiers in immunology · 2023Review
- Transarterial Embolization for Active Gastrointestinal Bleeding: Predictors of Early Mortality and Early Rebleeding.Journal of personalized medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmergency surgery or transarterial embolization (TAE) are options for the treatment of recurrent or refractory nonvariceal upper gastrointestinal bleeding. Surgery has the disadvantage of high rates of postoperative morbidity and mortality. Embolization has become more available and has the advantage of avoiding laparotomy in this often unfit and elderly population.
objectiveTo carry out a systematic review and meta-analysis of all studies that have directly compared TAE with emergency surgery in the treatment of major upper gastrointestinal bleeding that has failed therapeutic upper gastrointestinal endoscopy.
methodsA literature search of Ovid MEDLINE, Embase, and Google Scholar was performed. The primary outcomes were all-cause mortality and rates of rebleeding. The secondary outcomes were length of stay and postoperative complications.
resultsA total of nine studies with 711 patients (347 who had embolization and 364 who had surgery) were analyzed. Patients in the TAE group were more likely to have ischemic heart disease (odds ratio [OR] =1.99; 95% confidence interval [CI]: 1.33, 2.98; P=0.0008; I (2)=67% [random effects model]) and be coagulopathic (pooled OR =2.23; 95% CI: 1.29, 3.87; P=0.004; I (2)=33% [fixed effects model]). Compared with TAE, surgery was associated with a lower risk of rebleeding (OR =0.41; 95% CI: 0.22, 0.77; P<0.0001; I (2)=55% [random effects]). There was no difference in mortality (OR =0.70; 95% CI: 0.48, 1.02; P=0.06; I (2)=44% [fixed effects]) between TAE and surgery.
conclusionWhen compared with surgery, TAE had a significant increased risk of rebleeding rates after TAE; however, there were no differences in mortality rates. These findings are subject to multiple sources of bias due to poor quality studies. These findings support the need for a well-designed clinical trial to ascertain which technique is superior.
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Registered trials
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