Evidence map›Paper›PMID 24790439›Full record

ArticleInternational journal of nanomedicine2014

Preparation and characterization of polylactide/poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) hybrid fibers for potential application in bone tissue engineering.

YueLong Wang, Gang Guo, HaiFeng Chen, Xiang Gao, RangRang Fan, DongMei Zhang, LiangXue Zhou

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

YueLong WangState Key Laboratory of Biotherapy and Cancer Center, Chengdu, People's Republic of China ; Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.
Gang GuoState Key Laboratory of Biotherapy and Cancer Center, Chengdu, People's Republic of China.
HaiFeng ChenDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.
Xiang GaoState Key Laboratory of Biotherapy and Cancer Center, Chengdu, People's Republic of China.
RangRang FanState Key Laboratory of Biotherapy and Cancer Center, Chengdu, People's Republic of China.
DongMei ZhangState Key Laboratory of Biotherapy and Cancer Center, Chengdu, People's Republic of China.
LiangXue ZhouDepartment of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to develop a kind of osteogenic biodegradable composite graft consisting of human placenta-derived mesenchymal stem cell (hPMSC) material for site-specific repair of bone defects and attenuation of clinical symptoms. The novel nano- to micro-structured biodegradable hybrid fibers were prepared by electrospinning. The characteristics of the hybrid membranes were investigated by a range of methods, including Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry. Morphological study with scanning electron microscopy showed that the average fiber diameter and the number of nanoscale pores on each individual fiber surface decreased with increasing concentration of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCEC). The prepared polylactide (PLA)/PCEC fibrous membranes favored hPMSC attachment and proliferation by providing an interconnected, porous, three-dimensional mimicked extracellular environment. What is more, hPMSCs cultured on the electrospun hybrid PLA/PCEC fibrous scaffolds could be effectively differentiated into bone-associated cells by positive alizarin red staining. Given the good cellular response and excellent osteogenic potential in vitro, the electrospun PLA/PCEC fibrous scaffolds could be one of the most promising candidates for bone tissue engineering.

Indexed as

Tissue ScaffoldsBone SubstitutesBone TransplantationCells, CulturedEquipment DesignEquipment Failure AnalysisFeasibility StudiesFemaleHumansLactatesMaterials TestingMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteogenesisPolyestersPolyethylene GlycolsBone SubstitutesLactateslactide-caprolactone copolymerPolyestersPolyethylene Glycolspoly(lactic acid-ethylene glycol)bone tissue engineeringelectrospinninghPMSCsPCECPLA

Identifiers

PMID24790439
PMCPMC4000186

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.