ArticlePatient preference and adherence2014
Clinical outcomes of transfusion-associated iron overload in patients with refractory chronic anemia.
Article in Patient preference and adherence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Influence of transfusions, hemodialysis and extracorporeal life support on hyperferritinemia in critically ill patients.PloS one · 2021Article
- Ferroptosis Is a Potential Novel Diagnostic and Therapeutic Target for Patients With Cardiomyopathy.Frontiers in cell and developmental biology · 2021Review
- Paroxysmal nocturnal hemoglobinuria: patient journey and burden of disease.Journal of managed care & specialty pharmacy · 2020Review
- Evaluation of Liver Iron Content by Magnetic Resonance Imaging in Children with Acute Lymphoblastic Leukemia after Cessation of TreatmentTurkish journal of haematology : official journal of Turkish Society of Haematology · 2020Article
- Artificial Blood: The History and Current Perspectives of Blood Substitutes.Discoveries (Craiova, Romania) · 2020Review
- Iron Overload Mimicking Conditions Skews Bone Marrow Dendritic Cells Differentiation into MHCIIInternational journal of molecular sciences · 2020Article
- Iron chelation effect of curcumin and baicalein on aplastic anemia mouse model with iron overload.Iranian journal of basic medical sciences · 2019Article
- Medical and laboratory assessment for regular blood donors in Sulaimani Blood Bank, Iraq.Patient preference and adherence · 2018Article
- [MRI monitoring in diagnosis and follow-up of iron overload].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015Article
- Desferrithiocin: a search for clinically effective iron chelators.Journal of medicinal chemistry · 2014Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to evaluate the clinical outcomes of transfusion-associated iron overload in patients with chronic refractory anemia.
methodsClinical manifestations, main organ function, results of computed tomography (CT), endocrine evaluation, and serum ferritin levels were analyzed retrospectively in 13 patients who were transfusion-dependent for more than 1 year (receiving >50 units of red blood cells) to determine the degree of iron overload and efficacy of iron-chelating therapy.
resultsSerum ferritin levels increased to 1,830-5,740 ng/mL in all patients. Ten patients had abnormal liver function. The CT Hounsfield units in the liver increased significantly in eleven patients, and were proportional to their serum ferritin levels. Skin pigmentation, liver dysfunction, and endocrine dysfunction were observed in nine patients with serum ferritin >3,500 ng/mL, eight of whom have since died. Interestingly, serum ferritin levels did not decrease significantly in nine transfusion-dependent patients who had received 15-60 days of iron-chelating therapy.
conclusionTransfusion-dependent patients may progress to secondary iron overload with organ impairment, which may be fatal in those who are heavily iron-overloaded. The CT Hounsfield unit is a sensitive indicator of iron overload in the liver. Iron chelation therapy should be initiated when serum ferritin is >1,000 ng/mL and continued until it is <1,000 ng/mL in transfusional iron-overloaded patients.
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