ReviewClinical ophthalmology (Auckland, N.Z.)2014
Ocular manifestations of idiopathic aplastic anemia: retrospective study and literature review.
Review in Clinical ophthalmology (Auckland, N.Z.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Elaboration of a prognostic model associated with retinal hemorrhage in hemophagocytic lymphohistiocytosis.Annals of medicine · 2026Article
- Multimodal Imaging Features of Retinal Lesions in Hemophagocytic Lymphohistiocytosis: A Clinical Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- An Update to Biomechanical and Biochemical Principles of Retinal Injury in Child Abuse.Children (Basel, Switzerland) · 2024Review
- Severe retinal hemorrhages at various levels with a serous retinal detachment in a pediatric patient with aplastic anemia-A case report.Frontiers in medicine · 2023Article
- Unusual Cause of Vision Loss in a Case of Lupus.Mediterranean journal of rheumatology · 2022Article
- Two red boats in the eye: subhyaloid haemorrhages in anaemic retinopathy secondary to idiopathic aplastic anaemia.BMJ case reports · 2020Article
- Vision loss, tractional retinal detachment, and profound anemia due to rectal carcinoma.Clinical case reports · 2020Article
- Treatment of Radiation Retinopathy with Intravitreal Injection of Ranibizumab (LucentisInternational medical case reports journal · 2020Article
- Retinopathy in severe aplastic anaemia.BMJ case reports · 2019Article
- Routine funduscopy in immune thrombocytopenic purpura-is it really necessary?European journal of pediatrics · 2019Article
- [Retinal manifestation in hematological diseases].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2018Article
- Hemorrhagic Retinopathy after Spondylosis Surgery and Seizure.Optometry and vision science : official publication of the American Academy of Optometry · 2015Article
- Valsalva-Like Retinopathy Secondary to Pancytopenia following Induction of Etoposide and Ifosfamide.Case reports in ophthalmological medicine · 2015Article
- Roth spots revealing idiopathic aplastic anemia.Oman journal of ophthalmologyArticle
- Bilateral Spontaneous Hyphemas in a Patient with Aplastic Anemia.Case reports in ophthalmologyArticle
- Spontaneously resolved severe retinopathy associated with aplastic anemia.Oman journal of ophthalmologyArticle
- PERIPHERAL RETINOPATHY ASSOCIATED WITH APLASTIC ANEMIA.Retinal cases & brief reportsArticle
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aplastic anemia (AA) is a rare disease with few reports on its ophthalmic manifestations. The ocular findings are described in a retrospective consecutive series of 719 AA Korean patients followed at the Hematology Clinic of The Catholic University of Korea. Out of a total of 719 patients, 269 patients had eye examinations, 156 patients had retinal evaluation, and 37 (23.7%) had retinal findings. These 37 patients had unilateral retinal hemorrhage in seven and bilateral retinal hemorrhage in 30 with mean hemoglobin of 6.6 g/dL (range 2.7-12.6 g/dL) and platelet counts of 18.8×10(9)/L (range 4-157×10(9)/L); central retinal vein occlusion-like picture occurred in nine patients and these had similar rheology to the rest of the subjects; optic disc edema, cotton-wool spots, macular edema, and dry eyes occurred in two, three, five, and three patients, respectively. In this Korean series of 141 subjects with AA, systemic bleeding occurred in 24.8% of subjects, retinal hemorrhage in 37% of subjects, and any bleeding site (eye or elsewhere) occurred in 47.5% of subjects with AA. A literature review (1958-2010) of 200 AA cases revealed retinal hemorrhages in 56%, subhyaloid or vitreous hemorrhage in 9%, peripheral retinal vasculopathy in 5.5%, and cotton-wool spots, Sjögren's syndrome, or optic disc edema in 4% each. The prevalence of retinopathy among series of AA patients varied from 20% to 28.3%, which is consistent with the Korean series of 24.8%. Management of AA patients needs to involve multiple specialties, including hematologists, ophthalmologists, and infectious disease specialists.
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