ArticleSleep2014
Acute sleep deprivation enhances post-infection sleep and promotes survival during bacterial infection in Drosophila.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Sleep-dependent clearance of brain lipids by peripheral blood cells.bioRxiv : the preprint server for biology · 2025Article
- Quiescence Enhances Survival during Viral Infection inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila.Sleep · 2024Article
- The NFκBbioRxiv : the preprint server for biology · 2023Article
- Sleep and Cellular Stress.Current opinion in physiology · 2020Article
- The Sleep-Immune Crosstalk in Health and Disease.Physiological reviews · 2019Review
- Linking immunity and sickness-induced sleep.Science (New York, N.Y.) · 2019Article
- A sleep-inducing gene,Science (New York, N.Y.) · 2019Article
- The neurobiological basis of sleep: Insights from Drosophila.Neuroscience and biobehavioral reviews · 2018Review
- The Sleep in Caenorhabditis elegans: What We Know Until Now.Molecular neurobiology · 2018Review
- A mechanism for sickness sleep: lessons from invertebrates.The Journal of physiology · 2017Review
- Interleukin 37 expression in mice alters sleep responses to inflammatory agents and influenza virus infection.Neurobiology of sleep and circadian rhythms · 2017Article
- Circadian Rhythms and Sleep inGenetics · 2017Review
- Transgenerational plasticity following a dual pathogen and stress challenge in fruit flies.BMC evolutionary biology · 2016Article
- Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol?Anesthesiology · 2016Article
- FMRFamide signaling promotes stress-induced sleep in Drosophila.Brain, behavior, and immunity · 2015Article
- The neuron-specific interleukin-1 receptor accessory protein is required for homeostatic sleep and sleep responses to influenza viral challenge in mice.Brain, behavior, and immunity · 2015Article
- Sleep deprivation and divergent toll-like receptor-4 activation of cellular inflammation in aging.Sleep · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSleep is known to increase as an acute response to infection. However, the function of this behavioral response in host defense is not well understood. To address this problem, we evaluated the effect of acute sleep deprivation on post-infection sleep and immune function in Drosophila.
settingLaboratory.
participantsDrosophila melanogaster. METHODS AND
resultsFlies were subjected to sleep deprivation before (early DEP) or after (late DEP) bacterial infection. Relative to a non-deprived control, flies subjected to early DEP had enhanced sleep after infection as well as increased bacterial clearance and survival outcome. Flies subjected to late DEP experienced enhanced sleep following the deprivation period, and showed a modest improvement in survival outcome. Continuous DEP (early and late DEP) throughout infection also enhanced sleep later during infection and improved survival. However, improved survival in flies subjected to late or continuous DEP did not occur until after flies had experienced sleep. During infection, both early and late DEP enhanced NFκB transcriptional activity as measured by a luciferase reporter (κB-luc) in living flies. Early DEP also increased NFκB activity prior to infection. Flies that were deficient in expression of either the Relish or Dif NFκB transcription factors showed normal responses to early DEP. However, the effect of early DEP on post-infection sleep and survival was abolished in double mutants, which indicates that Relish and Dif have redundant roles in this process.
conclusionsAcute sleep deprivation elevated NFκB-dependent activity, increased post-infection sleep, and improved survival during bacterial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.