Evidence map›Paper›PMID 24790261›Full record

ArticleSleep2014

Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer.

Oxana Palesh, Arianna Aldridge-Gerry, Jamie M Zeitzer, Cheryl Koopman, Eric Neri, Janine Giese-Davis, Booil Jo, Helena Kraemer, Bita Nouriani, David Spiegel

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05093426 (Personalised Electronic Record Supported Two-Stage Observational Study of Sleep in Patients With Breast Cancer), which is not on this map. Cited by 132 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 6 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05093426 completednot on this mapstarted 2022, after this paper: background citation

Personalised Electronic Record Supported Two-Stage Observational Study of Sleep in Patients With Breast Cancer

TypeobservationalSponsorClosed Loop MedicineRan2022 to 2022Enrolled226ConditionsInsomnia, Breast CancerArmsStage 2 Digital sleep diary app
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 6 syntheses or guidelines pooled it, 227 citations in OpenAlex.

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  6. Prevalence and risk factors of sleep disturbances in breast cancersurvivors: systematic review and meta-analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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  7. Integrated psychosocial, sleep, and immunonutritional intervention improves psychological adaptation, sleep disturbance, and inflammatory activation in rectal cancer: a randomized controlled trial.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Oxana PaleshDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Arianna Aldridge-GerryDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Jamie M ZeitzerDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Cheryl KoopmanDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Eric NeriDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Janine Giese-DavisDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA ; Tom Baker Cancer Centre, Psychosocial Resources, Calgary, Canada.
Booil JoDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Helena KraemerDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Bita NourianiDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
David SpiegelDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Stanford University · US

Funding

XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI RASGON, NATALIE L · 1985 to 2008
$32.4M
Stress, The HPA and Health in AgingP01AG018784 · NIA · STANFORD UNIVERSITY · PI SPIEGEL, DAVID · 2001 to 2008
$8.7M
Brief Behavioral Intervention for Insomnia During ChemotherapyR01CA181659 · NCI · STANFORD UNIVERSITY · PI PALESH, OXANA G · 2014 to 2018
$3.1M
Sleep, Circadian, Hormonal Dysregulation, and Breast Cancer SurvivalR01CA118567 · NCI · STANFORD UNIVERSITY · PI SPIEGEL, DAVID · 2006 to 2010
$2.3M
Management of Insomnia in Cancer PatientsK07CA132916 · NCI · UNIVERSITY OF ROCHESTER · PI PALESH, OXANA G · 2008 to 2012
$679k
NCI NIH HHS CA118567NCI NIH HHS K07CA132916NCI NIH HHS R01CA118567,NCI NIH HHS R01 CA181659NCRR NIH HHS 5 M01 RR000070-44NIA NIH HHS AG18784
6 · The paper itself

Abstract

backgroundPoor sleep, prevalent among cancer survivors, is associated with disrupted hormonal circadian rhythms and poor quality of life. Using a prospective research design, this study aimed to clarify the relationship between objective measures of sleep efficiency and sleep disruption with survival among women with advanced breast cancer.

methodWe examined sleep quality and duration via wrist-worn actigraphy and sleep diaries for 3 days among 97 women in whom advanced breast cancer was diagnosed (age = 54.6 ± 9.8 years). Sleep efficiency was operationalized using actigraphy as the ratio of total sleep time to total sleep time plus wake after sleep onset.

resultsAs hypothesized, better sleep efficiency was found to predict a significant reduction in overall mortality (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.94-0.98; P < 0.001) at median 6 y follow-up. This relationship remained significant (HR, 0.94; 95% CI, 0.91-0.97; P < 0.001) even after adjusting for other known prognostic factors (age, estrogen receptor status, cancer treatment, metastatic spread, cortisol levels, and depression). Secondary hypotheses were also supported (after adjusting for baseline prognostic factors) showing that less wake after sleep onset (HR, 0.41; 95% CI, 0.25-0.67; P < 0.001), fewer wake episodes, (HR, 0.93; 95% CI, 0.88-0.98; P = 0.007); and shorter wake episode duration (HR, 0.29; 95% CI, 0.14-0.58; P < 0.001) also contributed to reductions in overall mortality.

conclusionsThese findings show that better sleep efficiency and less sleep disruption are significant independent prognostic factors in women with advanced breast cancer. Further research is needed to determine whether treating sleep disruption with cognitive behavioral and/or pharmacologic therapy could improve survival in women with advanced breast cancer.

Indexed as

ActigraphyAdultAgedAged, 80 and overBreast NeoplasmsFemaleHumansMiddle AgedPrognosisProspective StudiesSelf ReportSleepSleep Initiation and Maintenance DisordersSurvival AnalysisTime FactorsWakefulnessadvanced breast cancersleep disruptionsleep efficacysurvivalwake after sleep onset

Identifiers

PMID24790261
PMCPMC3985107
OpenAlexW1988374824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.