ReviewHaematologica2014
Nature and importance of follicular lymphoma precursors.
Review in Haematologica, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Molecular Biomarkers in Prediction of High-Grade Transformation and Outcome in Patients with Follicular Lymphoma: A Comprehensive Systemic Review.International journal of molecular sciences · 2024Pooled it
- Splenosis involved by in situ follicular B-cell neoplasm.Virchows Archiv : an international journal of pathology · 2025Article
- Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes.Cell reports. Medicine · 2025Article
- Oral squamous cell carcinoma with synchronous follicular lymphoma: A rare case report.SAGE open medical case reports · 2024Article
- The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas.Blood advances · 2023Article
- Disease-Defining Molecular Features of Primary Cutaneous B-Cell Lymphomas: Implications for Classification and Treatment.The Journal of investigative dermatology · 2023Review
- Precursory or early lesions of follicular lymphoma: clinical features, pathology, and genetics.Journal of clinical and experimental hematopathology : JCEH · 2023Review
- Follicular lymphoma: updates for pathologists.Journal of pathology and translational medicine · 2022Review
- "Double hit" B-lymphoblastic lymphoma with concurrentTranslational cancer research · 2021Article
- Germinal Center Cells Turning to the Dark Side: Neoplasms of B Cells, Follicular Helper T Cells, and Follicular Dendritic Cells.Frontiers in oncology · 2020Review
- Clonally related duodenal-type follicular lymphoma andHaematologica · 2019Article
- [Revised version of the 4th edition of the WHO classification of malignant lymphomas : What is new?]Der Pathologe · 2019Review
- Unraveling Tumor Heterogeneity in an Apparently Monolithic Disease: BCL2 and Other Players in the Genetic Landscape of Nodal Follicular Lymphoma.Frontiers in medicine · 2019Review
- t(14;18)-positive B cells: is it seed or soil?Blood · 2018Article
- From genetics to the clinic: a translational perspective on follicular lymphoma.Nature reviews. Cancer · 2018Review
- 18F-Fluorodeoxyglucose positron emission tomography computed tomography detection threshold in follicular lymphoma: A case report.Medicine · 2017Article
- The Microscope as a Tool for Disease Discovery-A Personal Voyage.Annual review of pathology · 2017Review
- Infections and Follicular Lymphoma: is there a Link?Mediterranean journal of hematology and infectious diseases · 2017Review
- The heterogeneity of follicular lymphomas: from early development to transformation.Virchows Archiv : an international journal of pathology · 2016Review
- MYD88 L265P mutation analysis helps define nodal lymphoplasmacytic lymphoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
It is now widely recognized that cancer development is a protracted process requiring the stepwise acquisition of multiple oncogenic events. In humans, this process can take decades, if not a lifetime, blurring the notion of 'healthy' individuals. Follicular lymphoma exemplifies this multistep pathway of oncogenesis. In recent years, variants of follicular lymphoma have been recognized that appear to represent clonal B-cell expansions at an early stage of follicular lymphoma lymphomagenesis. These include follicular lymphoma in situ, duodenal follicular lymphoma, partial involvement by follicular lymphoma, and in the blood circulating follicular lymphoma-like B cells. Recent genetic studies have identified similarities and differences between the early lesions and overt follicular lymphoma, providing important information for understanding their biological evolution. The data indicate that there is already genomic instability at these early stages, even in instances with a low risk for clinical progression. The overexpression of BCL2 in t(14;18)-positive B cells puts them at risk for subsequent genetic aberrations when they re-enter the germinal center and are exposed to the influences of activation-induced cytidine deaminase and somatic hypermutations. The emerging data provide a rationale for clinical management and, in the future, may identify genetic risk factors that warrant early therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.