ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
MRI-based measurements of aerosol deposition in the lung of healthy and elastase-treated rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
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- Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer.Cancers · 2021Review
- An Inhalable Theranostic System for Local Tuberculosis Treatment Containing an Isoniazid Loaded Metal Organic Framework Fe-MIL-101-NH2-From Raw MOF to Drug Delivery System.Pharmaceutics · 2019Article
- Patient-specific modeling of aerosol delivery in healthy and asthmatic adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI.Molecular imaging and biology · 2019Article
- Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method.Flow, turbulence and combustion · 2019Article
- Iron-Based Metal-Organic Frameworks as a Theranostic Carrier for Local Tuberculosis Therapy.Pharmaceutical research · 2018Article
- Article
- Novel multi-functional europium-doped gadolinium oxide nanoparticle aerosols facilitate the study of deposition in the developing rat lung.Nanoscale · 2016Article
- Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.Journal of molecular histology · 2016Article
- Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies.Journal of biomechanics · 2015Article
- Comparison of CT-derived ventilation maps with deposition patterns of inhaled microspheres in rats.Experimental lung research · 2015Article
- Scale dependence of structure-function relationship in the emphysematous mouse lung.Frontiers in physiology · 2015Article
- Increase in relative deposition of fine particles in the rat lung periphery in the absence of gravity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments.Annals of biomedical engineering · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Aerosolized drugs are increasingly being used to treat chronic lung diseases or to deliver therapeutics systemically through the lung. The influence of disease, such as emphysema, on particle deposition is not fully understood. With the use of magnetic resonance imaging (MRI), the deposition pattern of iron oxide particles with a mass median aerodynamic diameter of 1.2 μm was assessed in the lungs of healthy and elastase-treated rats. Tracheostomized rats were ventilated with particles, at a tidal volume of 2.2 ml, and a breathing frequency of 80 breaths/min. Maximum airway pressure was significantly lower in the elastase-treated (Paw = 7.71 ± 1.68 cmH2O) than in the healthy rats (Paw = 10.43 ± 1.02 cmH2O; P < 0.01). This is consistent with an increase in compliance characteristic of an emphysema-like lung structure. Following exposure, lungs were perfusion fixed and imaged in a 3T MR scanner. Particle concentration in the different lobes was determined based on a relationship with the MR signal decay rate, R2 (*). Whole lung particle deposition was significantly higher in the elastase-treated rats (CE,part = 3.03 ± 0.61 μm/ml) compared with the healthy rats (CH,part = 1.84 ± 0.35 μm/ml; P < 0.01). However, when particle deposition in each lobe was normalized by total deposition in the lung, there was no difference between the experimental groups. However, the relative dispersion [RD = standard deviation/mean] of R2 (*) was significantly higher in the elastase-treated rats (RDE = 0.32 ± 0.02) compared with the healthy rats (RDH = 0.25 ± 0.02; P < 0.01). These data show that particle deposition is higher and more heterogeneously distributed in emphysematous lungs compared with healthy lungs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.