ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Altering the sex determination pathway in Drosophila fat body modifies sex-specific stress responses.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Sex differences in the regulation and function of cellular immunity in Drosophila.PLoS genetics · 2026Article
- Sexually dimorphic ATF4 expression in the fat confers female stress tolerance in Drosophila melanogaster.Genetics · 2026Article
- An RNA Interference Tool to Silence Genes inInternational journal of molecular sciences · 2022Article
- Fear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila.Cell death & disease · 2021Article
- Article
- DomesticatedGenes · 2020Article
- Sex differences in the response to oxidative and proteolytic stress.Redox biology · 2020Review
- Mitochondrial peroxiredoxins are essential in regulating the relationship between Drosophila immunity and aging.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- High-Fat Diet Induces Oxidative Stress and MPK2 and HSP83 Gene Expression in Drosophila melanogaster.Oxidative medicine and cellular longevity · 2016Article
- Response to stress in Drosophila is mediated by gender, age and stress paradigm.Stress (Amsterdam, Netherlands) · 2015Article
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2 authors at 1 institution in 1 country.
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Abstract
The stress response in Drosophila melanogaster reveals sex differences in behavior, similar to what has been observed in mammals. However, unlike mammals, the sex determination pathway in Drosophila is well established, making this an ideal system to identify factors involved in the modulation of sex-specific responses to stress. In this study, we show that the Drosophila fat body, which has been shown to be important for energy homeostasis and sex determination, is a dynamic tissue that is altered in response to stress in a sex and time-dependent manner. We manipulated the sex determination pathway in the fat body via targeted expression of transformer and transformer-2 and analyzed these animals for changes in their response to stress. In the majority of cases, manipulation of transformer or transformer-2 was able to change the physiological output in response to starvation and oxidative stress to that of the opposite sex. Our data also uncover the possibility of additional downstream targets for transformer and transformer-2 that are separate from the sex determination pathway and can influence behavioral and physiological responses.
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