Evidence map›Paper›PMID 24789594›Full record

ArticleJournal of neurointerventional surgery2015

Primary stentriever versus combined stentriever plus aspiration thrombectomy approaches: in vitro stroke model comparison.

Maxim Mokin, Ciprian N Ionita, Swetadri Vasan Setlur Nagesh, Stephen Rudin, Elad I Levy, Adnan H Siddiqui

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurointerventional surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. A novel method for preparing clot analogs under dynamic vortical flow for testing mechanical thrombectomy devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  3. Review
  4. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Article
  5. Article
  6. In vitro models for the experimental evaluation of mechanical thrombectomy devices in acute ischemic stroke.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. A Review of the Advancements in theFrontiers in medical technology · 2022
    Review
  12. Review
  13. Article
  14. Evaluation of challenges and limitations of mechanical thrombectomy using 3D printed neurovascular phantoms.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  15. Article
  16. Comparison of FlowGateExperimental and therapeutic medicine · 2020
    Article
  17. Article
  18. Article
  19. Review
  20. Role of Balloon Guide Catheter in Modern Endovascular Thrombectomy.Journal of Korean Neurosurgical Society · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maxim MokinDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA.
Ciprian N IonitaDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.
Swetadri Vasan Setlur NageshDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Electrical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA.
Stephen RudinDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Physiology and Biophysics, University at Buffalo, State University of New York, Buffalo, New York, USA.
Elad I LevyDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.
Adnan H SiddiquiDepartment of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, USA Toshiba Stroke and Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, USA.
University at Buffalo, State University of New York · USToshiba (United States) · US

Funding

Micro-Radiographic Imager for Neuroovascular InterventionsR01EB002873 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUDIN, STEPHEN · 2003 to 2015
$5.6M
Hemodynamic Induction of Pathologic Remodeling Leading to Intracranial AneurysmsR01NS064592 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MENG, HUI · 2009 to 2013
$1.7M
NIBIB NIH HHS 2R01EB002873NIBIB NIH HHS R01 EB002873NINDS NIH HHS R01 NS064592
6 · The paper itself

Abstract

backgroundArtificial stroke models can be used for testing various thrombectomy devices.

objectiveTo determine the value of combined stentriever-aspiration thrombectomy compared with the stentriever-alone approach.

methodsWe designed an in vitro model of the intracranial circulation with a focus on the middle cerebral artery (MCA) that closely resembles the human intracranial circulation. After introducing fresh clot in the MCA, we used conventional biplane angiography and microangiographic fluoroscopy to compare recanalization rates and occurrence of emboli in new, unaffected territory for thrombectomy approaches in which a stentriever (Solitaire flow restoration stentriever, Covidien) was used alone or in combination with continuous manual aspiration through a Navien catheter (Covidien).

resultsIn a total of 22 experiments (11 for each approach), successful clot delivery to the MCA was achieved in all cases. Successful angiographic recanalization (thrombolysis in cerebral infarction score of 2b-3) was achieved more frequently with the combined stentriever-aspiration approach than with the stentriever-alone approach (in 10 vs 4 experiments, p=0.023). Emboli in new territory occurred in three experiments with the stentriever-alone approach, and none were seen with the combined approach (p=0.21).

conclusionsThe combined stentriever-aspiration approach to thrombectomy leads to better angiographic recanalization rates than use of the stentriever alone. Further experiments are needed to test the value of balloon-guide catheters and aspiration performed using other types of catheters and modes of aspiration.

Indexed as

Models, NeurologicalStentsAngiographyCerebrovascular CirculationHumansMiddle Cerebral ArteryStrokeThrombectomyThrombosisStrokeTechniqueThrombectomy

Identifiers

PMID24789594
PMCPMC4214918
OpenAlexW2044001568

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.