ArticleJournal of the Royal Society, Interface2014
Topological properties of robust biological and computational networks.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Two wrongs do not make a right: the assumption that an inhibitor acts as an inverse activator.Journal of mathematical biology · 2024Article
- Age-related differences in network controllability are mitigated by redundancy in large-scale brain networks.Communications biology · 2024Article
- Small vessel disease and cognitive reserve oppositely modulate global network redundancy and cognitive function: A study in middle-to-old aged community participants.Human brain mapping · 2024Article
- Trade-offs among brain structural network characteristics across the cognitive decline process in cerebral small vessel disease.Frontiers in aging neuroscience · 2024Article
- A robust core architecture of functional brain networks supports topological resilience and cognitive performance in middle- and old-aged adults.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Robustness in phenotypic plasticity and heterogeneity patterns enabled by EMT networks.Biophysical journal · 2022Article
- Overview of methods for characterization and visualization of a protein-protein interaction network in a multi-omics integration context.Frontiers in molecular biosciences · 2022Review
- The association between hippocampal volume and memory in pathological aging is mediated by functional redundancy.Neurobiology of aging · 2021Article
- Revealing protein-protein interactions at the transcriptome scale by sequencing.Molecular cell · 2021Article
- Frontoparietal network resilience is associated with protection against cognitive decline in Parkinson's disease.Communications biology · 2021Article
- Article
- Lower functional hippocampal redundancy in mild cognitive impairment.Translational psychiatry · 2021Article
- Substrate and cell fusion influence on slime mold network dynamics.Scientific reports · 2021Article
- Identification of robust genes in transcriptional regulatory network of Mycobacterium tuberculosis.IET systems biology · 2020Article
- Chaperome Networks - Redundancy and Implications for Cancer Treatment.Advances in experimental medicine and biology · 2020Review
- Adapting to stress - chaperome networks in cancer.Nature reviews. Cancer · 2018Review
- Age-Related Changes in Topological Degradation of White Matter Networks and Gene Expression in Chronic Schizophrenia.Brain connectivity · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Network robustness is an important principle in biology and engineering. Previous studies of global networks have identified both redundancy and sparseness as topological properties used by robust networks. By focusing on molecular subnetworks, or modules, we show that module topology is tightly linked to the level of environmental variability (noise) the module expects to encounter. Modules internal to the cell that are less exposed to environmental noise are more connected and less robust than external modules. A similar design principle is used by several other biological networks. We propose a simple change to the evolutionary gene duplication model which gives rise to the rich range of module topologies observed within real networks. We apply these observations to evaluate and design communication networks that are specifically optimized for noisy or malicious environments. Combined, joint analysis of biological and computational networks leads to novel algorithms and insights benefiting both fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.